{"doi":"10.1002/wsbm.1198","title":"Promise of personalized omics to precision medicine","abstract":"<jats:title>Abstract</jats:title><jats:p>The rapid development of high‐throughput technologies and computational frameworks enables the examination of biological systems in unprecedented detail. The ability to study biological phenomena at omics levels in turn is expected to lead to significant advances in personalized and precision medicine. Patients can be treated according to their own molecular characteristics. Individual omes as well as the integrated profiles of multiple omes, such as the genome, the epigenome, the transcriptome, the proteome, the metabolome, the antibodyome, and other omics information are expected to be valuable for health monitoring, preventative measures, and precision medicine. Moreover, omics technologies have the potential to transform medicine from traditional symptom‐oriented diagnosis and treatment of diseases toward disease prevention and early diagnostics. We discuss here the advances and challenges in systems biology‐powered personalized medicine at its current stage, as well as a prospective view of future personalized health care at the end of this review. <jats:italic>WIREs Syst Biol Med</jats:italic> 2013, 5:73–82. doi: 10.1002/wsbm.1198</jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Analytical and Computational Methods &gt; Analytical Methods</jats:p></jats:list-item>\n<jats:list-item><jats:p>Laboratory Methods and Technologies &gt; Genetic/Genomic Methods</jats:p></jats:list-item>\n<jats:list-item><jats:p>Translational, Genomic, and Systems Medicine &gt; Translational Medicine</jats:p></jats:list-item>\n</jats:list></jats:p>","journal":"WIREs Systems Biology and Medicine","year":2013,"id":13520,"datarank":10.457510988518607,"base_score":5.777652323222656,"endowment":5.777652323222656,"self_citation_contribution":0.8666478484833986,"citation_network_contribution":9.590863140035209,"self_endowment_contribution":0.8666478484833986,"citer_contribution":9.590863140035209,"corpus_percentile":null,"corpus_rank":null,"citation_count":322,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":110673,"name":"Michael Snyder","orcid":null,"position":1,"is_corresponding":false},{"id":6713,"name":"Rui Chen","orcid":"0000-0002-4227-7732","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.777652323222656,"endowment":5.777652323222656,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23184638","pmcid":"PMC4154620","openalex_id":"https://openalex.org/W2042445733","authors":[],"funders":[{"funder_name":"NHGRI NIH HHS","grant_id":"P50 HG002357","title":null},{"funder_name":"NHGRI NIH HHS","grant_id":"T32 HG000044","title":null}],"total_grants":2,"fwci":5.7766,"citation_percentile":0.97037697,"influential_citations":6,"citation_trend":[{"year":2013,"count":13},{"year":2014,"count":14},{"year":2015,"count":16},{"year":2016,"count":24},{"year":2017,"count":31},{"year":2018,"count":29},{"year":2019,"count":39},{"year":2020,"count":28},{"year":2021,"count":26},{"year":2022,"count":21},{"year":2023,"count":30},{"year":2024,"count":20},{"year":2025,"count":27},{"year":2026,"count":4}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/wsbm.1198","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/wsbm.1198","host_type":"BRONZE"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/wsbm.1198","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fwsbm.1198","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/wsbm.1198","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/wsbm.1198","host_type":"publisher"},{"url":"https://wires.onlinelibrary.wiley.com/doi/pdf/10.1002/wsbm.1198","host_type":"publisher"},{"url":"https://doi.org/10.1002/wsbm.1198","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23184638","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4154620","host_type":"repository"}],"fields_of_study":["Bioinformatics and Genomic Networks","Cancer Genomics and Diagnostics","Microbial Metabolic Engineering and Bioproduction","Medicine","Biology","Animals","Chromosome Mapping","Drug Discovery","Genome-Wide Association Study","Humans","Pharmacogenetics","Precision Medicine"],"mesh_terms":["Animals","Chromosome Mapping","Humans","Pharmacogenetics","Genome-Wide Association Study","Drug Discovery","Precision Medicine"],"keywords":["Personalized medicine","Omics","Precision medicine","Epigenome","Translational medicine","Systems medicine","Systems biology","Computational biology","Genomics","Metabolome","Data science","Computer science","Bioinformatics","Medicine","Genome","Biology","Metabolomics","Genetics","Pathology","DNA methylation"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-05-30T19:27:19.014308Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}