{"doi":"10.1002/wdev.132","title":"<i>Peromyscus</i> (deer mice) as developmental models","abstract":"<jats:p>Deer mice (<jats:italic>Peromyscus</jats:italic>) are the most common native North American mammals, and exhibit great natural genetic variation. Wild‐derived stocks from a number of populations are available from the <jats:italic>Peromyscus</jats:italic> Genetic Stock Center (<jats:styled-content style=\"fixed-case\">PGSC</jats:styled-content>). The <jats:styled-content style=\"fixed-case\">PGSC</jats:styled-content> also houses a number of natural variants and mutants (many of which appear to differ from <jats:italic>Mus</jats:italic>). These include metabolic, coat‐color/pattern, neurological, and other morphological variants/mutants. Nearly all these mutants are on a common genetic background, the <jats:italic>Peromyscus maniculatus</jats:italic> <jats:styled-content style=\"fixed-case\">BW</jats:styled-content> stock. <jats:italic>Peromyscus</jats:italic> are also superior behavior models in areas such as repetitive behavior and pair‐bonding effects, as multiple species are monogamous. While <jats:italic>Peromyscus</jats:italic> development generally resembles that of <jats:italic>Mus</jats:italic> and <jats:italic>Rattus</jats:italic>, prenatal stages have not been as thoroughly studied, and there appear to be intriguing differences (e.g., longer time spent at the two‐cell stage). Development is greatly perturbed in crosses between <jats:italic>P. maniculatus</jats:italic> (<jats:styled-content style=\"fixed-case\">BW</jats:styled-content>) and <jats:italic>Peromyscus polionotus</jats:italic> (<jats:styled-content style=\"fixed-case\">PO</jats:styled-content>). <jats:styled-content style=\"fixed-case\">BW</jats:styled-content> females crossed to <jats:styled-content style=\"fixed-case\">PO</jats:styled-content> males produce growth‐restricted, but otherwise healthy, fertile offspring which allows for genetic analyses of the many traits that differ between these two species. <jats:styled-content style=\"fixed-case\">PO</jats:styled-content> females crossed to <jats:styled-content style=\"fixed-case\">BW</jats:styled-content> males produce overgrown but severely dysmorphic conceptuses that rarely survive to late gestation. There are likely many more uses for these animals as developmental models than we have described here. <jats:italic>Peromyscus</jats:italic> models can now be more fully exploited due to the emerging genetic (full linkage map), genomic (genomes of four stocks have been sequenced) and reproductive resources.</jats:p><jats:p>This article is categorized under:\n<jats:list list-type=\"explicit-label\">\n<jats:list-item><jats:p>Establishment of Spatial and Temporal Patterns &gt; Regulation of Size, Proportion, and Timing</jats:p></jats:list-item>\n<jats:list-item><jats:p>Nervous System Development &gt; Vertebrates: General Principles</jats:p></jats:list-item>\n<jats:list-item><jats:p>Comparative Development and Evolution &gt; Model Systems</jats:p></jats:list-item>\n</jats:list></jats:p>","journal":"WIREs Developmental Biology","year":2014,"id":37586,"datarank":1.2508539582803135,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"self_citation_contribution":0.515098080672772,"citation_network_contribution":0.7357558776075416,"self_endowment_contribution":0.515098080672772,"citer_contribution":0.7357558776075416,"corpus_percentile":null,"corpus_rank":null,"citation_count":30,"citer_count":21,"citers_with_citation_signal":19,"citers_with_endowment":19,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":188055,"name":"Kimberly R. Shorter","orcid":null,"position":1,"is_corresponding":false},{"id":188056,"name":"Gabor Szalai","orcid":null,"position":2,"is_corresponding":false},{"id":188057,"name":"Michael R. Felder","orcid":null,"position":3,"is_corresponding":false},{"id":188058,"name":"Janet P. Crossland","orcid":null,"position":4,"is_corresponding":false},{"id":188059,"name":"Monika Veres","orcid":null,"position":5,"is_corresponding":false},{"id":188060,"name":"Jasmine E. Allen","orcid":null,"position":6,"is_corresponding":false},{"id":188061,"name":"Christopher D. Wiley","orcid":null,"position":7,"is_corresponding":false},{"id":188062,"name":"Amanda R. Duselis","orcid":null,"position":8,"is_corresponding":false},{"id":188063,"name":"Michael J. Dewey","orcid":null,"position":9,"is_corresponding":false},{"id":188064,"name":"Wallace D. Dawson","orcid":null,"position":10,"is_corresponding":false},{"id":188054,"name":"Paul B. Vrana","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":3.4339872044851463,"endowment":3.4339872044851463,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"24896658","pmcid":null,"openalex_id":"https://openalex.org/W1492985122","authors":[],"funders":[],"total_grants":0,"fwci":3.2103,"citation_percentile":0.90256348,"influential_citations":2,"citation_trend":[{"year":2014,"count":5},{"year":2015,"count":1},{"year":2016,"count":4},{"year":2017,"count":2},{"year":2018,"count":1},{"year":2019,"count":2},{"year":2020,"count":3},{"year":2021,"count":6},{"year":2024,"count":3},{"year":2025,"count":2},{"year":2026,"count":1}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/wdev.132","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/wdev.132","host_type":"BRONZE"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/wdev.132","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fwdev.132","host_type":"publisher"},{"url":"https://wires.onlinelibrary.wiley.com/doi/pdf/10.1002/wdev.132","host_type":"publisher"},{"url":"https://doi.org/10.1002/wdev.132","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/24896658","host_type":"repository"}],"fields_of_study":["Wildlife Ecology and Conservation","Genetic and phenotypic traits in livestock","Ecology and biodiversity studies","Biology","Medicine","Animals","Embryonic Development","Genetic Variation","Models, Animal","Peromyscus","Pigmentation","Reproduction"],"mesh_terms":["Animals","Peromyscus","Pigmentation","Reproduction","Genetic Variation","Models, Animal","Embryonic Development"],"keywords":["Peromyscus","Biology","Deer mouse","Offspring","Zoology","Evolutionary biology","Genetics","Pregnancy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.16620679.v1","title":"Additional file 1 of Genomic variation in captive deer mouse (Peromyscus maniculatus) populations","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.16620679","title":"Additional file 1 of Genomic variation in captive deer mouse (Peromyscus maniculatus) populations","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-10T20:05:25.150214Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}