{"doi":"10.1002/vrc2.70201","title":"Iris‐to‐cornea persistent pupillary membrane in a Beagle","abstract":"Persistent pupillary membranes (PPMs) occur commonly as congenital abnormalities in dogs and other species.1-3 The diagnosis is made when uveal strands, which are remnants of the embryonal pupillary membrane, fail to regress by 3 months of age.1-3 They were shown to be inherited in some dog breeds, such as Basenji, Pembroke Welsh Corgi, Chow Chow and English Mastiff, but the mode of inheritance remains unknown.2, 3 With the mildest and most common form of PPM, the uveal strands bridge from one location of the iris collarette to another with no detectable visual impairment.2, 3 Therefore, there is generally no concern about breeding dogs with these iris-to-iris PPMs.3 In contrast, PPMs bridging from the iris collarette to the lens or the cornea result in opacities, cataracts or leukomas, respectively, with the potential to affect eyesight.1-3 Hence, dogs affected with these more severe PPM forms should not be bred.3 We provide detailed clinical pictures showing multiple uveal strands originating from the iris collarette and inserting at one common location of the central inner cornea in the left eye of a 4-year-old female Beagle (Figure 1). Since the right eye was unaffected, the dog did not exhibit any behavioural signs of visual impairment. High-resolution images obtained by confocal scanning laser ophthalmoscopy and optical coherence tomography show in great detail the morphologic changes of the inner cornea at the PPM insertion site (Figure 2). To the best of our knowledge, we provide for the first time angiograms of canine PPMs, confirming the presence of perfused blood vessels within the uveal strands (Figure 3). András M. Komáromy and Christine D. Harman conceived and designed the project. András M. Komáromy acquired the funding. Christine D. Harman, Amanda L. Jacobson, Christopher G. Pirie, and András M. Komáromy acquired the images. Sydney G. Holt, Christine D. Harman, and András M. Komáromy analysed and interpreted the images. Sydney G. Holt and András M. Komáromy wrote the original draft. Sydney G. Holt, Christine D. Harman, Amanda L. Jacobson, Christopher G. Pirie and András M. Komáromy reviewed the paper. The authors thank the Michigan State University Campus Animal Resources staff for their technical assistance. The study was partially funded by NIH grants R01-EY025752 and R01-EY032478, and BrightFocus Foundation grantG2022007S. The authors declare they have no conflicts of interest related to this case report. This study adhered to the Association for Research in Vision and Ophthalmology Statement for the Use of Animals in Ophthalmic and Vision Research and was approved by the Michigan State University Institutional Animal Care and Use Committee. What is your diagnosis based on the ocular anterior segment changes shown in the left eye of this Beagle (Figure 1)? Answer: Iris-to-cornea persistent pupillary membranes. What major corneal change can be observed typically in dogs with iris-to-cornea persistent pupillary membranes? Focal disruption of the normal posterior corneal morphology Descemetocele Bullous keratopathy No change A. Focal disruption of the normal posterior corneal morphology Iris-to-cornea persistent pupillary membranes originate from the iris surface and insert in the inner cornea, resulting in focal disruption of the normal posterior corneal morphology, including corneal endothelium and Descemet's membrane. Clinically, this appears as focal pigmentation and white scar formation, or leukoma, of the inner cornea. Depending on the extent of the corneal opacification, there is a potential for visual impairment.","journal":"Veterinary Record Case Reports","year":2025,"id":575036,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9595,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":785761,"name":"Christine D. Harman","orcid":"0009-0005-8377-9797","position":1,"is_corresponding":false},{"id":1151636,"name":"Amanda L. Jacobson","orcid":null,"position":2,"is_corresponding":false},{"id":785764,"name":"Chris G. Pirie","orcid":"0000-0002-4664-3664","position":3,"is_corresponding":false},{"id":370917,"name":"András M. Komáromy","orcid":"0000-0002-8845-0588","position":4,"is_corresponding":false},{"id":1483060,"name":"Sydney G. Holt","orcid":null,"position":0,"is_corresponding":true}],"reference_count":1,"raw_metadata":null,"created_at":"2026-07-19T02:57:44.572630Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}