{"doi":"10.1002/trc2.70134","title":"A common outcome set for trials in dementia with Lewy bodies (DLB COS)","abstract":"INTRODUCTION: Methodological heterogeneity in dementia with Lewy bodies (DLB) trials contributes to publication bias and makes evidence synthesis and meta-analysis challenging. We aimed to develop a core outcome set for DLB (DLB COS) trials to improve consistency and comparability in DLB research. METHODS: We conducted a systematic review to identify outcomes and administered a two-stage Delphi survey to a diverse panel of lay and professional stakeholders. We asked respondents which outcomes should be prioritized and included in DLB COS. RESULTS: Forty-nine outcomes were presented to survey respondents. Consensus was reached regarding eight outcomes for the final DLB COS: delusions/paranoia; fluctuations in cognition, attention, and arousal; functioning; global cognition; hallucinations; quality of life; motor parkinsonism; and rapid eye movement sleep behavior disorder. DISCUSSION: If adopted, DLB COS can enhance the comparability of research findings and facilitate standardization and harmonization. Highlights: A systematic review revealed heterogeneity in dementia with Lewy bodies (DLB) study outcomes.Our study produced a DLB Core Outcome Set (DLB COS) comprising eight outcomes.DLB COS sets the minimum reporting standards for future trials.DLB-specific rating scales incorporating these outcomes are needed.Addressing this gap is a strategic priority in DLB research.","journal":"Alzheimer s & Dementia Translational Research & Clinical Interventions","year":2025,"id":521612,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.799,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1391939,"name":"Rachel Fitzpatrick","orcid":"0000-0002-8795-7627","position":1,"is_corresponding":false},{"id":332730,"name":"Sara M. Betzhold","orcid":null,"position":2,"is_corresponding":false},{"id":1391940,"name":"Gillian Daly","orcid":"0000-0003-0267-6728","position":3,"is_corresponding":false},{"id":1391941,"name":"Emily Kalfas","orcid":"0000-0003-3836-5438","position":4,"is_corresponding":false},{"id":1391942,"name":"Irina Kinchin","orcid":"0000-0003-0133-2763","position":5,"is_corresponding":false},{"id":108593,"name":"Dag Aarsland","orcid":"0000-0001-6314-216X","position":6,"is_corresponding":false},{"id":1392442,"name":"Ken Greaney","orcid":null,"position":7,"is_corresponding":false},{"id":1391943,"name":"Emilia Grycuk","orcid":"0000-0002-0162-7548","position":8,"is_corresponding":false},{"id":1016088,"name":"Ann‐Kristin Folkerts","orcid":"0000-0003-2168-140X","position":9,"is_corresponding":false},{"id":1016095,"name":"Elke Kalbe","orcid":"0000-0001-8603-2545","position":10,"is_corresponding":false},{"id":850090,"name":"Federico Rodríguez‐Porcel","orcid":"0000-0002-7492-5095","position":11,"is_corresponding":false},{"id":22149,"name":"Ian J. Saldanha","orcid":"0000-0002-2062-3382","position":12,"is_corresponding":false},{"id":1391944,"name":"Valerie Smith","orcid":"0000-0003-2249-6038","position":13,"is_corresponding":false},{"id":108609,"name":"John‐Paul Taylor","orcid":"0000-0001-7958-6558","position":14,"is_corresponding":false},{"id":1391945,"name":"Rachel Thompson","orcid":"0009-0005-2953-633X","position":15,"is_corresponding":false},{"id":850091,"name":"Kathryn A Wyman‐Chick","orcid":"0000-0002-5057-5094","position":16,"is_corresponding":false},{"id":690510,"name":"Iracema Leroi","orcid":"0000-0003-1822-3643","position":17,"is_corresponding":false},{"id":1392443,"name":"and The DLB COS Delphi Group","orcid":null,"position":18,"is_corresponding":false},{"id":707424,"name":"Joseph Kane","orcid":"0000-0002-8479-9977","position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T02:49:44.558743Z","pmid":"40657378","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}