{"doi":"10.1002/trc2.70081","title":"Measuring time saved in Alzheimer's disease: What is a meaningful slowing of progression?","abstract":"INTRODUCTION: Minimal clinically important differences (MCIDs) for Alzheimer's disease (AD) have previously been estimated using clinician-based anchors. However, MCIDs have been criticized for not reflecting the preferences of people living with AD (PLWAD). Furthermore, interpretations of clinical trial results have been criticized for conflating within-person meaningfulness thresholds and between-group differences. Here, we simulate scenarios of disease slowing and compare those to published MCIDs. METHODS: Scenarios of 5%-95% disease slowing were simulated using Alzheimer's Disease Neuroimaging Initiative (ADNI) data. Time saved and point differences on the Clinical Dementia Rating scale-Sum of Boxes (CDR-SB) were estimated for these scenarios and compared to published MCIDs. RESULTS: Scenario analyses resulted in estimates of time saved at ∼3 weeks-17 months and mean changes at 0.08-1.5 CDR-SB points over 18 months. The often referenced MCID for mild cognitive impairment (0.98) thereby corresponded to 11 months slowing, whereas the MCID for mild dementia (1.63) corresponded to >17 months slowing. DISCUSSION: Translating trial endpoints to estimates of time saved supports that often-referenced MCIDs may not be aligned with realistic and meaningful slowing of clinical progression. Highlights: AD slowing of clinical progression by 5%-95% resulted in 0.74-17 months saved and 0.08-1.5 CDR-SB points change at 18 months.Slowing of at least 60% or 11 months of time saved over 18 months met an often-cited MCID threshold of 0.98 points for mild cognitive impairment.For mild AD dementia, an MCID of 1.63 meant that even an 18-month delay over 18 months would be considered only borderline meaningful-a face invalid and unrealistic proposition.","journal":"Alzheimer s & Dementia Translational Research & Clinical Interventions","year":2025,"id":523081,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9584,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1018450,"name":"Linus Jönsson","orcid":"0000-0001-5751-6292","position":1,"is_corresponding":false},{"id":618790,"name":"Alireza Atri","orcid":"0000-0003-4405-6973","position":2,"is_corresponding":false},{"id":1395536,"name":"Russ Paulsen","orcid":null,"position":3,"is_corresponding":false},{"id":842645,"name":"Soeren Mattke","orcid":"0000-0003-4666-9132","position":4,"is_corresponding":false},{"id":1395537,"name":"Julie Hviid Hahn‐Pedersen","orcid":null,"position":5,"is_corresponding":false},{"id":1395538,"name":"Pepa Polavieja","orcid":null,"position":6,"is_corresponding":false},{"id":1395134,"name":"Thomas Maltesen","orcid":"0000-0002-3988-2456","position":7,"is_corresponding":false},{"id":1395135,"name":"Teresa León","orcid":"0000-0001-5171-4159","position":8,"is_corresponding":false},{"id":1046613,"name":"Anders Gustavsson","orcid":"0000-0002-2147-2969","position":9,"is_corresponding":false},{"id":19445,"name":"Alzheimer's Disease Neuroimaging Initiative","orcid":null,"position":10,"is_corresponding":false},{"id":244604,"name":"Krista L. Lanctôt","orcid":"0000-0001-7024-6637","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T02:49:58.707747Z","pmid":"40225240","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}