{"doi":"10.1002/syn.21506","title":"Methamphetamine self‐administration acutely decreases monoaminergic transporter function","abstract":"<jats:title>Abstract</jats:title><jats:p>Numerous preclinical studies have demonstrated that noncontingent methamphetamine (METH) administration rapidly decreases both dopamine (DA) transporter (DAT) and vesicular monoamine‐2 transporter (VMAT‐2) function. Because of the importance of transporter function to the abuse and neurotoxic liabilities of METH, and previous research indicating that the effects of noncontingent METH treatment do not necessarily predict effects of contingent exposure, the present study examined the acute impact of METH self‐administration on these transporters. Results revealed that five days of METH self‐administration (4 h/session; 0.06 mg/infusion) decreased DAT and VMAT‐2 activity, as assessed in synaptosomes and vesicles, respectively, prepared from striatal tissue 1 h after the final self‐administration session. METH self‐administration increased core body temperatures as well. Brain METH and amphetamine (AMPH) levels, assessed 1 h after the final self‐administration session, were approximately twice greater in high‐pressing rats compared to low‐pressing rats despite similar changes in DAT function. In conclusion, the present manuscript is the first to describe transporter function and METH/AMPH levels after self‐administration in rodents. These data provide a foundation to investigate complex questions including how the response of dopaminergic systems to METH self‐administration contributes to contingent‐related processes such as dependence. Synapse, 2012. © 2011 Wiley Periodicals, Inc.</jats:p>","journal":"Synapse","year":2012,"id":657685,"datarank":1.2538201674469263,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.81215432057196,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.81215432057196,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":17,"citers_with_citation_signal":14,"citers_with_endowment":14,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":598777,"name":"Kristen A. Stout","orcid":"0000-0002-3641-5326","position":1,"is_corresponding":false},{"id":1716845,"name":"Paula L. Vieira‐Brock","orcid":null,"position":2,"is_corresponding":false},{"id":1716848,"name":"Scott C. Allen","orcid":null,"position":3,"is_corresponding":false},{"id":1716850,"name":"Shannon M. Nielsen","orcid":null,"position":4,"is_corresponding":false},{"id":1562165,"name":"Diana G. Wilkins","orcid":null,"position":5,"is_corresponding":false},{"id":1715690,"name":"Glen R. Hanson","orcid":null,"position":6,"is_corresponding":false},{"id":1341305,"name":"Annette E. Fleckenstein","orcid":null,"position":7,"is_corresponding":false},{"id":530050,"name":"Lisa M. McFadden","orcid":"0000-0002-1657-7758","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Methamphetamine self‐administration acutely decreases monoaminergic transporter function","abstract":"<jats:title>Abstract</jats:title><jats:p>Numerous preclinical studies have demonstrated that noncontingent methamphetamine (METH) administration rapidly decreases both dopamine (DA) transporter (DAT) and vesicular monoamine‐2 transporter (VMAT‐2) function. Because of the importance of transporter function to the abuse and neurotoxic liabilities of METH, and previous research indicating that the effects of noncontingent METH treatment do not necessarily predict effects of contingent exposure, the present study examined the acute impact of METH self‐administration on these transporters. Results revealed that five days of METH self‐administration (4 h/session; 0.06 mg/infusion) decreased DAT and VMAT‐2 activity, as assessed in synaptosomes and vesicles, respectively, prepared from striatal tissue 1 h after the final self‐administration session. METH self‐administration increased core body temperatures as well. Brain METH and amphetamine (AMPH) levels, assessed 1 h after the final self‐administration session, were approximately twice greater in high‐pressing rats compared to low‐pressing rats despite similar changes in DAT function. In conclusion, the present manuscript is the first to describe transporter function and METH/AMPH levels after self‐administration in rodents. These data provide a foundation to investigate complex questions including how the response of dopaminergic systems to METH self‐administration contributes to contingent‐related processes such as dependence. Synapse, 2012. © 2011 Wiley Periodicals, Inc.</jats:p>","is_dataset_classified":null,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22120988","pmcid":"PMC3962658","openalex_id":"https://openalex.org/W2147112444","authors":[],"funders":[{"funder_name":"PHS HHS","grant_id":"013367","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"DA09407","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA004222","title":null},{"funder_name":"PHS HHS","grant_id":"00378","title":null},{"funder_name":"PHS HHS","grant_id":"04222","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"K05 DA000378","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA009407","title":null},{"funder_name":"PHS HHS","grant_id":"00869","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA000869","title":null},{"funder_name":"PHS HHS","grant_id":"11389","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"K02 DA019447","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"R01 DA011389","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"P01 DA013367","title":null},{"funder_name":"PHS HHS","grant_id":"019447","title":null}],"total_grants":14,"fwci":0.6544,"citation_percentile":0.61575973,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":4},{"year":2014,"count":1},{"year":2015,"count":1},{"year":2016,"count":1},{"year":2018,"count":1},{"year":2020,"count":1},{"year":2021,"count":1},{"year":2022,"count":4},{"year":2023,"count":1},{"year":2025,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fsyn.21506","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/syn.21506","host_type":"publisher"},{"url":"https://doi.org/10.1002/syn.21506","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22120988","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3962658","host_type":"repository"}],"fields_of_study":["Neurotransmitter Receptor Influence on Behavior","Neuroscience and Neuropharmacology Research","Receptor Mechanisms and Signaling","Amphetamine","Animals","Corpus Striatum","Dopamine","Dopamine Agents","Dopamine Plasma Membrane Transport Proteins","Male","Methamphetamine","Rats","Rats, Sprague-Dawley","Self Administration","Vesicular Monoamine Transport Proteins"],"mesh_terms":["Amphetamine","Animals","Corpus Striatum","Dopamine","Male","Methamphetamine","Self Administration","Dopamine Agents","Rats, Sprague-Dawley","Dopamine Plasma Membrane Transport Proteins","Vesicular Monoamine Transport Proteins","Rats"],"keywords":["Meth-","Methamphetamine","Monoaminergic","Dopaminergic","Self-administration","Dopamine transporter","Amphetamine","Pharmacology","Vesicular monoamine transporter 2","Monoamine neurotransmitter","Transporter","Dopamine","Reuptake","Medicine","Chemistry","Internal medicine","Serotonin","Biochemistry","Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T02:01:20.497093Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}