{"doi":"10.1002/stem.3436","title":"Bone-Forming Perivascular Cells: Cellular Heterogeneity and Use for Tissue Repair","abstract":"Abstract Mesenchymal progenitor cells are broadly distributed across perivascular niches—an observation conserved between species. One common histologic zone with a high frequency of mesenchymal progenitor cells within mammalian tissues is the tunica adventitia, the outer layer of blood vessel walls populated by cells with a fibroblastic morphology. The diversity and functions of (re)generative cells present in this outermost perivascular niche are under intense investigation; we have reviewed herein our current knowledge of adventitial cell potential with a somewhat narrow focus on bone formation. Antigens of interest to functionally segregate adventicytes are discussed, including CD10, CD107a, aldehyde dehydrogenase isoforms, and CD140a, among others. Purified adventicytes (such as CD10+, CD107alow, and CD140a+ cells) have stronger osteogenic potential and promote bone formation in vivo. Recent bone tissue engineering applications of adventitial cells are also presented. A better understanding of perivascular progenitor cell subsets may represent a beneficial advance for future efforts in tissue repair and bioengineering.","journal":"Stem Cells","year":2021,"id":189240,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.942,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":286481,"name":"Yiyun Wang","orcid":"0000-0003-0775-4377","position":1,"is_corresponding":false},{"id":751348,"name":"Mario Gomez-Salazar","orcid":"0000-0003-3144-7983","position":2,"is_corresponding":false},{"id":301493,"name":"Ginny Ching‐Yun Hsu","orcid":"0000-0001-5923-3413","position":3,"is_corresponding":false},{"id":286479,"name":"Stefano Negri","orcid":"0000-0003-2218-6654","position":4,"is_corresponding":false},{"id":751349,"name":"Zhao Li","orcid":"0000-0002-9276-9129","position":5,"is_corresponding":false},{"id":751350,"name":"Winters R. Hardy","orcid":"0000-0002-4542-8444","position":6,"is_corresponding":false},{"id":751351,"name":"Lijun Ding","orcid":"0000-0002-6330-7945","position":7,"is_corresponding":false},{"id":460351,"name":"Bruno Péault","orcid":null,"position":8,"is_corresponding":false},{"id":250819,"name":"Aaron W. James","orcid":"0000-0002-2002-622X","position":9,"is_corresponding":false},{"id":250818,"name":"Jiajia Xu","orcid":"0000-0002-6084-2029","position":0,"is_corresponding":true}],"reference_count":82,"raw_metadata":null,"created_at":"2026-07-18T23:49:14.547082Z","pmid":"34252260","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}