{"doi":"10.1002/sta4.402","title":"Classification of longitudinal brain networks with an application to understanding superior aging","abstract":"This paper studies the problem of classifying longitudinal structural brain networks to identify meaningful substructures and their time‐varying effects. The problem is motivated by a subpopulation of healthy older adults who can maintain excellent cognitive functions across time, while others usually have cognitive decline in aging. It is of substantial scientific interest to study neurological mechanisms behind this successful aging phenomena; however, existing statistical tools for longitudinal networks are very limited. We propose a structured classification method that could identify a set of small outcome‐relevant subgraphs and estimate the age effect of each signal subgraph from the longitudinal network predictors, as well as an efficient algorithm for model estimation. Application of this method to the Alzheimer's Disease Neuroimaging Initiative (ADNI) data identifies a small set of brain regions whose connectivity strengths are predictive of successful cognitive aging, which has more appealing interpretation and better predictive performance compared with unstructured classification methods.","journal":"Stat","year":2021,"id":210302,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9451,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":334184,"name":"Zhengwu Zhang","orcid":"0000-0002-9047-8838","position":1,"is_corresponding":false},{"id":376574,"name":"Lu Wang","orcid":"0000-0001-7472-7008","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-18T23:52:12.491146Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}