{"doi":"10.1002/smll.202307585","title":"High‐Affinity Host–Guest Recognition for Efficient Assembly and Enzymatic Responsiveness of DNA Nanostructures","abstract":"Abstract The combination of multiple orthogonal interactions enables hierarchical complexity in self‐assembled nanoscale materials. Here, efficient supramolecular polymerization of DNA origami nanostructures is demonstrated using a multivalent display of small molecule host–guest interactions. Modification of DNA strands with cucurbit[7]uril (CB[7]) and its adamantane guest, yielding a supramolecular complex with an affinity of order 10 10 m −1 , directs hierarchical assembly of origami monomers into 1D nanofibers. This affinity regime enables efficient polymerization; a lower‐affinity β‐cyclodextrin–adamantane complex does not promote extended structures at a similar valency. Finally, the utility of the high‐affinity CB[7]–adamantane interactions is exploited to enable responsive enzymatic actuation of origami nanofibers assembled using peptide linkers. This work demonstrates the power of high‐affinity CB[7]–guest recognition as an orthogonal axis to drive self‐assembly in DNA nanotechnology.","journal":"Small","year":2023,"id":359840,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9438,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":925597,"name":"Abhay Prasad","orcid":"0000-0003-3310-3287","position":1,"is_corresponding":false},{"id":867011,"name":"Alex Buchberger","orcid":"0000-0003-3412-8945","position":2,"is_corresponding":false},{"id":878759,"name":"Lei Zou","orcid":"0000-0001-8247-7184","position":3,"is_corresponding":false},{"id":908381,"name":"Julio Bernal‐Chanchavac","orcid":"0000-0001-5093-4248","position":4,"is_corresponding":false},{"id":582372,"name":"T. MacCulloch","orcid":"0000-0001-5875-3361","position":5,"is_corresponding":false},{"id":908383,"name":"Nour Eddine Fahmi","orcid":"0000-0001-6829-9756","position":6,"is_corresponding":false},{"id":275749,"name":"Hao Yan","orcid":"0000-0001-7397-9852","position":7,"is_corresponding":false},{"id":925600,"name":"Fei Zhang","orcid":"0000-0002-3177-7547","position":8,"is_corresponding":false},{"id":878760,"name":"Matthew J. Webber","orcid":"0000-0003-3111-6228","position":9,"is_corresponding":false},{"id":504881,"name":"Nicholas Stephanopoulos","orcid":"0000-0001-7859-410X","position":10,"is_corresponding":false},{"id":908382,"name":"Raghu Pradeep Narayanan","orcid":"0000-0002-7036-9706","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T01:13:57.361401Z","pmid":"37849034","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}