{"doi":"10.1002/smll.202203357","title":"Wide‐Field Three‐Dimensional Depth‐Invariant Cellular‐Resolution Imaging of the Human Retina","abstract":"Three-dimensional (3D) cellular-resolution imaging of the living human retina over a large field of view will bring a great impact in clinical ophthalmology, potentially finding new biomarkers for early diagnosis and improving the pathophysiological understanding of ocular diseases. While hardware-based and computational adaptive optics (AO) optical coherence tomography (OCT) have been developed to achieve cellular-resolution retinal imaging, these approaches support limited 3D imaging fields, and their high cost and intrinsic hardware complexity limit their practical utility. Here, this work demonstrates 3D depth-invariant cellular-resolution imaging of the living human retina over a 3 × 3 mm field of view using the first intrinsically phase-stable multi-MHz retinal swept-source OCT and novel computational defocus and aberration correction methods. Single-acquisition imaging of photoreceptor cells, retinal nerve fiber layer, and retinal capillaries is presented across unprecedented imaging fields. By providing wide-field 3D cellular-resolution imaging in the human retina using a standard point-scan architecture routinely used in the clinic, this platform proposes a strategy for expanded utilization of high-resolution retinal imaging in both research and clinical settings.","journal":"Small","year":2023,"id":349013,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9482,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1091772,"name":"Sunhong Jeong","orcid":"0000-0002-8539-0823","position":1,"is_corresponding":false},{"id":1091773,"name":"Joosung Lee","orcid":"0000-0001-7981-2762","position":2,"is_corresponding":false},{"id":352248,"name":"Tae Shik Kim","orcid":null,"position":3,"is_corresponding":false},{"id":322012,"name":"Boy Braaf","orcid":null,"position":4,"is_corresponding":false},{"id":320697,"name":"Benjamin J. Vakoc","orcid":"0000-0002-6623-3515","position":5,"is_corresponding":false},{"id":350964,"name":"Wang‐Yuhl Oh","orcid":"0000-0002-7766-3086","position":6,"is_corresponding":false},{"id":326974,"name":"ByungKun Lee","orcid":"0000-0001-8520-988X","position":0,"is_corresponding":true}],"reference_count":71,"raw_metadata":null,"created_at":"2026-07-19T01:12:10.335697Z","pmid":"36642824","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}