{"doi":"10.1002/smll.202200311","title":"Ultraflexible and Stretchable Intrafascicular Peripheral Nerve Recording Device with Axon‐Dimension, Cuff‐Less Microneedle Electrode Array","abstract":"Peripheral nerve mapping tools with higher spatial resolution are needed to advance systems neuroscience, and potentially provide a closed-loop biomarker in neuromodulation applications. Two critical challenges of microscale neural interfaces are 1) how to apply them to small peripheral nerves, and 2) how to minimize chronic reactivity. A flexible microneedle nerve array (MINA) is developed, which is the first high-density penetrating electrode array made with axon-sized silicon microneedles embedded in low-modulus thin silicone. The design, fabrication, acute recording, and chronic reactivity to an implanted MINA, are presented. Distinctive units are identified in the rat peroneal nerve. The authors also demonstrate a long-term, cuff-free, and suture-free fixation manner using rose bengal as a light-activated adhesive for two time-points. The tissue response is investigated at 1-week and 6-week time-points, including two sham groups and two MINA-implanted groups. These conditions are quantified in the left vagus nerve of rats using histomorphometry. Micro computed tomography (micro-CT) is added to visualize and quantify tissue encapsulation around the implant. MINA demonstrates a reduction in encapsulation thickness over previously quantified interfascicular methods. Future challenges include techniques for precise insertion of the microneedle electrodes and demonstrating long-term recording.","journal":"Small","year":2022,"id":242286,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":38,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9486,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":345266,"name":"Ahmad A. Jiman","orcid":"0000-0001-8832-4672","position":1,"is_corresponding":false},{"id":345267,"name":"Elizabeth C. Bottorff","orcid":"0000-0002-7802-4171","position":2,"is_corresponding":false},{"id":306026,"name":"Paras R. Patel","orcid":"0000-0001-6146-718X","position":3,"is_corresponding":false},{"id":872650,"name":"Dilara Meli","orcid":"0000-0002-9032-1697","position":4,"is_corresponding":false},{"id":270094,"name":"Elissa Welle","orcid":"0000-0001-5141-7656","position":5,"is_corresponding":false},{"id":346560,"name":"David C. Ratze","orcid":null,"position":6,"is_corresponding":false},{"id":435533,"name":"Leif A. Havton","orcid":"0000-0003-1561-4331","position":7,"is_corresponding":false},{"id":270103,"name":"Cynthia A. Chestek","orcid":"0000-0002-9671-7051","position":8,"is_corresponding":false},{"id":641943,"name":"Stephen W.P. Kemp","orcid":"0000-0002-5608-3584","position":9,"is_corresponding":false},{"id":345268,"name":"Tim M. Bruns","orcid":"0000-0003-1692-0541","position":10,"is_corresponding":false},{"id":294969,"name":"Euisik Yoon","orcid":"0000-0002-2127-1200","position":11,"is_corresponding":false},{"id":263224,"name":"John P. Seymour","orcid":"0000-0002-3783-7838","position":12,"is_corresponding":false},{"id":872649,"name":"Dongxiao Yan","orcid":"0000-0002-3688-2346","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T00:23:05.485568Z","pmid":"35491522","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}