{"doi":"10.1002/sim.9850","title":"On the integration of decision trees with mixture cure model","abstract":"The mixture cure model is widely used to analyze survival data in the presence of a cured subgroup. Standard logistic regression-based approaches to model the incidence may lead to poor predictive accuracy of cure, specifically when the covariate effect is non-linear. Supervised machine learning techniques can be used as a better classifier than the logistic regression due to their ability to capture non-linear patterns in the data. However, the problem of interpret-ability hangs in the balance due to the trade-off between interpret-ability and predictive accuracy. We propose a new mixture cure model where the incidence part is modeled using a decision tree-based classifier and the proportional hazards structure for the latency part is preserved. The proposed model is very easy to interpret, closely mimics the human decision-making process, and provides flexibility to gauge both linear and non-linear covariate effects. For the estimation of model parameters, we develop an expectation maximization algorithm. A detailed simulation study shows that the proposed model outperforms the logistic regression-based and spline regression-based mixture cure models, both in terms of model fitting and evaluating predictive accuracy. An illustrative example with data from a leukemia study is presented to further support our conclusion.","journal":"Statistics in Medicine","year":2023,"id":334726,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":701159,"name":"Suvra Pal","orcid":"0000-0001-9864-9489","position":1,"is_corresponding":false},{"id":1049206,"name":"Wisdom Aselisewine","orcid":null,"position":0,"is_corresponding":true}],"reference_count":47,"raw_metadata":null,"created_at":"2026-07-19T01:09:53.742667Z","pmid":"37503905","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}