{"doi":"10.1002/sctm.19-0419","title":"A Systematic Review and Meta-Analysis of Cell-Based Interventions in Experimental Diabetic Kidney Disease","abstract":"Regenerative, cell-based therapy is a promising treatment option for diabetic kidney disease (DKD), which has no cure. To prepare for clinical translation, this systematic review and meta-analysis summarized the effect of cell-based interventions in DKD animal models and treatment-related factors modifying outcomes. Electronic databases were searched for original investigations applying cell-based therapy in diabetic animals with kidney endpoints (January 1998-May 2019). Weighted or standardized mean differences were estimated for kidney outcomes and pooled using random-effects models. Subgroup analyses tested treatment-related factor effects for outcomes (creatinine, urea, urine protein, fibrosis, and inflammation). In 40 studies (992 diabetic rodents), therapy included mesenchymal stem/stromal cells (MSC; 61%), umbilical cord/amniotic fluid cells (UC/AF; 15%), non-MSC (15%), and cell-derived products (13%). Tissue sources included bone marrow (BM; 65%), UC/AF (15%), adipose (9%), and others (11%). Cell-based therapy significantly improved kidney function while reducing injury markers (proteinuria, histology, fibrosis, inflammation, apoptosis, epithelial-mesenchymal-transition, oxidative stress). Preconditioning, xenotransplantation, and disease-source approaches were effective. MSC and UC/AF cells had greater effect on kidney function while cell products improved fibrosis. BM and UC/AF tissue sources more effectively improved kidney function and proteinuria vs adipose or other tissues. Cell dose, frequency, and administration route also imparted different benefits. In conclusion, cell-based interventions in diabetic animals improved kidney function and reduced injury with treatment-related factors modifying these effects. These findings may aid in development of optimal repair strategies through selective use of cells/products, tissue sources, and dose administrations to allow for successful adaptation of this novel therapeutic in human DKD.","journal":"Stem Cells Translational Medicine","year":2021,"id":156495,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":54,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9442,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":662493,"name":"Tala Abedalqader","orcid":null,"position":1,"is_corresponding":false},{"id":662494,"name":"Gift Ben-Bernard","orcid":null,"position":2,"is_corresponding":false},{"id":661469,"name":"Jayla Mondy","orcid":"0000-0003-3379-0937","position":3,"is_corresponding":false},{"id":662495,"name":"Xiaohui Bian","orcid":null,"position":4,"is_corresponding":false},{"id":256713,"name":"Sabena M. Conley","orcid":null,"position":5,"is_corresponding":false},{"id":661470,"name":"Xiangyang Zhu","orcid":"0000-0002-4469-0758","position":6,"is_corresponding":false},{"id":436374,"name":"Sandra M. Herrmann","orcid":"0000-0002-3700-4537","position":7,"is_corresponding":false},{"id":661471,"name":"Aleksandra Kukla","orcid":"0000-0001-9576-5687","position":8,"is_corresponding":false},{"id":647939,"name":"Elizabeth C. Lorenz","orcid":"0000-0003-1012-9409","position":9,"is_corresponding":false},{"id":333683,"name":"Seo Rin Kim","orcid":"0000-0003-3552-0519","position":10,"is_corresponding":false},{"id":661472,"name":"Bjorg Thorsteinsdottir","orcid":"0000-0002-4397-728X","position":11,"is_corresponding":false},{"id":253564,"name":"Lilach O. Lerman","orcid":"0000-0002-3271-3887","position":12,"is_corresponding":false},{"id":56883,"name":"Mohammad Hassan Murad","orcid":"0000-0001-5502-5975","position":13,"is_corresponding":false},{"id":253557,"name":"LaTonya J. Hickson","orcid":"0000-0002-7485-336X","position":0,"is_corresponding":true}],"reference_count":106,"raw_metadata":null,"created_at":"2026-07-18T23:44:13.017332Z","pmid":"34106528","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}