{"doi":"10.1002/pul2.12450","title":"Delta‐like ligand 4 inhibitor drug treatment induces pulmonary hypertension in cancer clinical trials","abstract":"Delta-like ligand 4 (DLL-4) inhibitor drugs are an emerging cancer treatment. In clinical trials for solid organ malignancies, intravenous administration of monoclonal antibodies that inhibit DLL-4 is associated with development of pulmonary hypertension, in the absence of left ventricular dysfunction. Analysis of 13 clinical trials showed that pulmonary hypertension is a complication of DLL-4 inhibition.","journal":"Pulmonary Circulation","year":2024,"id":505901,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9542,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":956619,"name":"Nolan M. Winicki","orcid":"0000-0002-0784-2679","position":1,"is_corresponding":false},{"id":1264116,"name":"Cristian Puerta","orcid":"0000-0002-0953-0150","position":2,"is_corresponding":false},{"id":391139,"name":"Moises Hernandez","orcid":"0000-0002-7651-2673","position":3,"is_corresponding":false},{"id":266298,"name":"Jason X.‐J. Yuan","orcid":"0000-0002-0685-4862","position":4,"is_corresponding":false},{"id":55517,"name":"Patricia A. Thistlethwaite","orcid":"0000-0002-1986-7304","position":5,"is_corresponding":false},{"id":1264540,"name":"Casandra E. Besse","orcid":null,"position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-19T02:10:50.984927Z","pmid":"39525948","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}