{"doi":"10.1002/pul2.12216","title":"Novel left ventricular mechanical index in pulmonary arterial hypertension","abstract":"Abstract Ventricular interdependence plays an important role in pulmonary arterial hypertension (PAH). It can decrease left ventricular (LV) longitudinal strain (LVLS) and lead to a leftward displacement (“transverse shortening”) of the interventricular septum (sTS). For this study, we hypothesized the ratio of LVLS/sTS would be a sensitive marker of systolic ventricular interactions in PAH. In a cross‐sectional cohort of patients with PAH ( n = 57) and matched controls ( n = 57), we quantified LVLS and septal TS in the amplitude and time domain. We then characterized LV phenotypes using upset plots, ventricular interactions using network analysis, and longitudinal analysis in a representative cohort of 45 patients. We also measured LV metrics in mice subjected to pulmonary arterial banding (PAB) using a 7 T magnetic resonance imaging at baseline, Week 1, and Week 7 post‐PAB ( N = 9). Patients with PAH had significantly reduced absolute LVLS (15.4 ± 3.4 vs. 20.1 ± 2.3%, p < 0.0001), higher sTS (53.0 ± 12.2 vs. 28.0 ± 6.2%, p < 0.0001) and lower LVLS/sTS (0.30 ± 0.09 vs. 0.75 ± 0.16, p < 0.0001) compared to controls. Reduced LVLS/sTS was observed in 89.5% of patients, while diastolic dysfunction, impaired LVLS (<16%), and LV atrophy were observed in 73.7%, 52.6%, and 15.8%, respectively. In the longitudinal cohort, changes in LVLS/sTS were closely associated with changes in N‐terminal pro B‐type natriuretic peptide ( r = 0.73, p < 0.0001) as well as survival. Mice subjected to PAB showed significant RV systolic dysfunction and decreased LVLS/sTS compared to sham animals. We conclude that in PAH, LVLV/sTS is a simple ratio that can reflect ventricular systolic interactions.","journal":"Pulmonary Circulation","year":2023,"id":363753,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9595,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":961578,"name":"Everton J. Santana","orcid":"0000-0002-6014-9857","position":1,"is_corresponding":false},{"id":88211,"name":"Tatiana Kuznetsova","orcid":"0000-0003-4293-4576","position":2,"is_corresponding":false},{"id":352638,"name":"Nicholas Cauwenberghs","orcid":"0000-0001-8059-7692","position":3,"is_corresponding":false},{"id":773799,"name":"František Sabovčik","orcid":"0000-0001-8275-6431","position":4,"is_corresponding":false},{"id":1118580,"name":"Lindsey Chun","orcid":null,"position":5,"is_corresponding":false},{"id":1118581,"name":"N. Francisco","orcid":null,"position":6,"is_corresponding":false},{"id":422852,"name":"Vitaly O. Kheyfets","orcid":"0000-0002-3466-1910","position":7,"is_corresponding":false},{"id":225213,"name":"Michael Salerno","orcid":"0000-0001-7051-1031","position":8,"is_corresponding":false},{"id":92046,"name":"Roham T. Zamanian","orcid":"0000-0002-0734-0994","position":9,"is_corresponding":false},{"id":422856,"name":"Edda Spiekerkoetter","orcid":"0000-0002-3868-5186","position":10,"is_corresponding":false},{"id":17281,"name":"Francois Haddad","orcid":"0000-0002-9648-7671","position":11,"is_corresponding":false},{"id":748081,"name":"Kenzo Ichimura","orcid":"0000-0002-5734-335X","position":0,"is_corresponding":true}],"reference_count":42,"raw_metadata":null,"created_at":"2026-07-19T01:14:32.510714Z","pmid":"37063750","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}