{"doi":"10.1002/psc.70003","title":"Synthesis of Anabaenopeptins With a Strategic Eye Toward N‐Terminal Sequence Diversity","abstract":"A divergent synthesis strategy was developed for producing various anabaenopeptins (AP) for harmful algal bloom monitoring. The synthesis involved on-resin stepwise pentapeptide assembly on a MeDbz linker then N-α-ureido amino acid attachment and cyclization. To manage N-methylated amino acids, modified coupling conditions were employed. Lysine's ε-amino group reacted with the activated MeDbz linker in a self-cleaving head-to-side chain cyclization. Cyclization conditions were optimized by screening different pH levels to control lysine α-amine cyclization and prevent hydrolysis. Global cleavage and purification afforded the pure anabaenopeptins. This approach proved effective as a general platform for anabaenopeptin synthesis, allowing rapid access to anabaenopeptins A, B, F, and oscillamide Y.","journal":"Journal of Peptide Science","year":2025,"id":561750,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9543,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1463999,"name":"Boddu S. Ramakrishna","orcid":"0000-0001-5148-4947","position":1,"is_corresponding":false},{"id":1464258,"name":"Zoee K. Harris","orcid":null,"position":2,"is_corresponding":false},{"id":1464259,"name":"Sydney C. Kasmer","orcid":null,"position":3,"is_corresponding":false},{"id":1096327,"name":"Dennis P. Anderson","orcid":null,"position":4,"is_corresponding":false},{"id":721566,"name":"Nicholas J. Peraino","orcid":null,"position":5,"is_corresponding":false},{"id":372205,"name":"Judy A. Westrick","orcid":"0000-0001-9112-5295","position":6,"is_corresponding":false},{"id":1422103,"name":"Jennifer L. Stockdill","orcid":"0000-0003-4238-6530","position":7,"is_corresponding":false},{"id":1060280,"name":"Venneti N. Murty","orcid":"0000-0003-2148-0106","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T02:56:01.883848Z","pmid":"39916497","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}