{"doi":"10.1002/prot.26310","title":"Atomic structure of the <i>Leishmania spp</i>. Hsp100 <scp>N‐domain</scp>","abstract":"Hsp100 is an ATP-dependent unfoldase that promotes protein disaggregation or facilitates the unfolding of aggregation-prone polypeptides marked for degradation. Recently, new Hsp100 functions are emerging. In Plasmodium, an Hsp100 drives malaria protein export, presenting a novel drug target. Whether Hsp100 has a similar function in other protists is unknown. We present the 1.06 Å resolution crystal structure of the Hsp100 N-domain from Leishmania spp., the causative agent of leishmaniasis in humans. Our structure reveals a network of methionines and aromatic amino acids that define the putative substrate-binding site and likely evolved to protect Hsp100 from oxidative damage in host immune cells.","journal":"Proteins Structure Function and Bioinformatics","year":2022,"id":292821,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9403,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":321525,"name":"Sukyeong Lee","orcid":"0000-0001-6054-6628","position":1,"is_corresponding":false},{"id":477425,"name":"Changsoo Chang","orcid":"0000-0003-1860-2969","position":2,"is_corresponding":false},{"id":483826,"name":"Nuri Sung","orcid":null,"position":3,"is_corresponding":false},{"id":426957,"name":"Lynn Soong","orcid":"0000-0003-3370-3434","position":4,"is_corresponding":false},{"id":345639,"name":"André Catic","orcid":"0000-0002-3572-7598","position":5,"is_corresponding":false},{"id":288891,"name":"Francis Tsai","orcid":"0000-0001-9349-1520","position":6,"is_corresponding":false},{"id":977299,"name":"Jonathan Mercado","orcid":"0000-0001-5440-1991","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T00:30:50.076284Z","pmid":"35122310","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}