{"doi":"10.1002/pro.70434","title":"Unfolding the history of protein <scp>HDX NMR</scp>","abstract":"I review the development of two-dimensional hydrogen-deuterium exchange (HDX) nuclear magnetic resonance (NMR) spectroscopy and highlight its importance to the study of protein structure and stability. This review presents a historical perspective beginning from the discovery of deuterium and its early uses, to the era of Linderstrøm-Lang and mechanistic studies, to the development of NMR and how the techniques came together to provide residue-level insight. I discuss recent developments, new applications, and offer a perspective about the future.","journal":"Protein Science","year":2025,"id":587378,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9599,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1390882,"name":"Jordyn M. Markle","orcid":"0000-0002-5452-0082","position":0,"is_corresponding":true}],"reference_count":215,"raw_metadata":null,"created_at":"2026-07-19T02:59:36.020030Z","pmid":"41457455","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}