{"doi":"10.1002/pro.4173","title":"Every protagonist has a sidekick: Structural aspects of human xeroderma pigmentosum‐binding proteins in nucleotide excision repair","abstract":"<jats:title>Abstract</jats:title><jats:p>The seven xeroderma pigmentosum proteins (XPps), XPA–XPG, coordinate the nucleotide excision repair (NER) pathway, promoting the excision of DNA lesions caused by exposition to ionizing radiation, majorly from ultraviolet light. Significant efforts are made to investigate NER since mutations in any of the seven XPps may cause the xeroderma pigmentosum and trichothiodystrophy diseases. However, these proteins collaborate with other pivotal players in all known NER steps to accurately exert their purposes. Therefore, in the old and ever‐evolving field of DNA repair, it is imperative to reexamine and describe their structures to understand NER properly. This work provides an up‐to‐date review of the protein structural aspects of the closest partners that directly interact and influence XPps: RAD23B, CETN2, DDB1, RPA (RPA70, 32, and 14), p8 (GTF2H5), and ERCC1. Structurally and functionally vital domains, regions, and critical residues are reexamined, providing structural lessons and perspectives about these indispensable proteins in the NER and other DNA repair pathways. By gathering all data related to the major human xeroderma pigmentosum‐interacting proteins, this review will aid newcomers on the subject and guide structural and functional future studies.</jats:p>","journal":"Protein Science","year":2021,"id":37919,"datarank":0.34116368495317795,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.029247453701202502,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.029247453701202502,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":4,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":189033,"name":"Bruno César Feltes","orcid":"0000-0002-2825-8295","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"34420242","pmcid":"PMC8521314","openalex_id":"https://openalex.org/W3195933833","authors":[],"funders":[{"funder_name":"Coordenação de Aperfeiçoamento de Pessoal de Nível Superior","grant_id":"001","title":null}],"total_grants":1,"fwci":0.4885,"citation_percentile":0.62214003,"influential_citations":0,"citation_trend":[{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":3},{"year":2025,"count":1}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4173","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4173","host_type":"BRONZE"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.4173","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/pro.4173","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/pro.4173","host_type":"publisher"},{"url":"https://doi.org/10.1002/pro.4173","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/34420242","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/8521314","host_type":"repository"}],"fields_of_study":["DNA Repair Mechanisms","CRISPR and Genetic Engineering","Porphyrin Metabolism and Disorders","Medicine","Biology","DNA","DNA Repair","DNA Repair Enzymes","DNA-Binding Proteins","Humans","Mutation","Xeroderma Pigmentosum"],"mesh_terms":["DNA","DNA Repair","DNA-Binding Proteins","Humans","Mutation","Xeroderma Pigmentosum","DNA Repair Enzymes"],"keywords":["Xeroderma pigmentosum","Nucleotide excision repair","DNA repair","ERCC1","Biology","Genetics","DNA damage","DNA","Pyrimidine dimer","DNA-binding protein","Computational biology","Transcription factor","Gene","protein structure","Ner","Gg-ner"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-10T21:45:06.326464Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}