{"doi":"10.1002/pro.3873","title":"Crystal structure of Nsp15 endoribonuclease <scp>NendoU</scp> from <scp>SARS‐CoV</scp> ‐2","abstract":"Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) is rapidly spreading around the world. There is no existing vaccine or proven drug to prevent infections and stop virus proliferation. Although this virus is similar to human and animal SARS-CoVs and Middle East Respiratory Syndrome coronavirus (MERS-CoVs), the detailed information about SARS-CoV-2 proteins structures and functions is urgently needed to rapidly develop effective vaccines, antibodies, and antivirals. We applied high-throughput protein production and structure determination pipeline at the Center for Structural Genomics of Infectious Diseases to produce SARS-CoV-2 proteins and structures. Here we report two high-resolution crystal structures of endoribonuclease Nsp15/NendoU. We compare these structures with previously reported homologs from SARS and MERS coronaviruses.","journal":"Protein Science","year":2020,"id":48657,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":367,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9424,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":226921,"name":"R. Jedrzejczak","orcid":"0000-0001-6375-7199","position":1,"is_corresponding":false},{"id":231323,"name":"N. Maltseva","orcid":"0000-0002-2871-465X","position":2,"is_corresponding":false},{"id":231324,"name":"Mateusz Wilamowski","orcid":"0000-0001-8760-0700","position":3,"is_corresponding":false},{"id":234152,"name":"M. Endres","orcid":null,"position":4,"is_corresponding":false},{"id":12333,"name":"Adam Godzik","orcid":"0000-0002-2425-852X","position":5,"is_corresponding":false},{"id":231325,"name":"K. Michalska","orcid":"0000-0001-7140-3649","position":6,"is_corresponding":false},{"id":91662,"name":"A. Joachimiak","orcid":"0000-0003-2535-6209","position":7,"is_corresponding":false},{"id":231322,"name":"Youngchang Kim","orcid":"0000-0002-1610-4889","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-18T20:35:18.908826Z","pmid":"32304108","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}