{"doi":"10.1002/pro.2524","title":"A brief overview of amyloids and Alzheimer's disease","abstract":"<jats:title>Abstract</jats:title><jats:p>Amyloid fibrils are self‐assembled fibrous protein aggregates that are associated with a number of presently incurable diseases such as Alzheimer's and Parkinson's disease. Millions of people worldwide suffer from amyloid diseases. This review summarizes the unique cross‐β structure of amyloid fibrils, morphological variations, the kinetics of amyloid fibril formation, and the cytotoxic effects of these fibrils and oligomers. Alzheimer's disease is also explored as an example of an amyloid disease to show the various approaches to treat these amyloid diseases. Finally, this review investigates the nanotechnological and biological applications of amyloid fibrils; as well as a summary of the typical biological pathways involved in the disposal of amyloid fibrils and their precursors.</jats:p>","journal":"Protein Science","year":2014,"id":31581,"datarank":4.9839817342097446,"base_score":5.135798437050262,"endowment":5.135798437050262,"self_citation_contribution":0.7703697655575394,"citation_network_contribution":4.213611968652205,"self_endowment_contribution":0.7703697655575394,"citer_contribution":4.213611968652205,"corpus_percentile":null,"corpus_rank":null,"citation_count":169,"citer_count":169,"citers_with_citation_signal":139,"citers_with_endowment":139,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":168942,"name":"Dave E. Dunstan","orcid":null,"position":1,"is_corresponding":false},{"id":168941,"name":"Sian‐Yang Ow","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.135798437050262,"endowment":5.135798437050262,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"25042050","pmcid":"PMC4286994","openalex_id":"https://openalex.org/W2128145834","authors":[],"funders":[],"total_grants":0,"fwci":3.6837,"citation_percentile":0.93563015,"influential_citations":4,"citation_trend":[{"year":2015,"count":4},{"year":2016,"count":10},{"year":2017,"count":7},{"year":2018,"count":9},{"year":2019,"count":18},{"year":2020,"count":16},{"year":2021,"count":18},{"year":2022,"count":15},{"year":2023,"count":21},{"year":2024,"count":25},{"year":2025,"count":16},{"year":2026,"count":10}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2524","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2524","host_type":"BRONZE"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/pro.2524","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpro.2524","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/pro.2524","host_type":"publisher"},{"url":"https://doi.org/10.1002/pro.2524","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/25042050","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4286994","host_type":"repository"}],"fields_of_study":["Alzheimer's disease research and treatments","Supramolecular Self-Assembly in Materials","Prion Diseases and Protein Misfolding","Medicine","Biology","Materials Science","Alzheimer Disease","Amyloid","Amyloidosis","Gene Expression Regulation","Humans","Models, Molecular","Protein Structure, Secondary"],"mesh_terms":["Alzheimer Disease","Amyloid","Amyloidosis","Gene Expression Regulation","Humans","Models, Molecular","Protein Structure, Secondary"],"keywords":["Fibril","Amyloid fibril","Amyloid (mycology)","Amyloid disease","Disease","Protein aggregation","Biochemistry of Alzheimer's disease","Protein folding","Chemistry","Alzheimer's disease","Amyloid β","Biophysics","Medicine","Amyloid precursor protein","Biochemistry","Biology","Pathology","Review","Amyloid Fibrils","Fibril Structure"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T07:42:39.461000Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}