{"doi":"10.1002/prm2.70031","title":"Single‐nucleotide polymorphisms in coronary artery disease: Biological complexity, risk architecture, and implications for precision prevention","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Coronary artery disease (CAD) is characterized by significant genetic diversity with interindividual genetic variation. Genomewide association studies have discovered many CAD‐associated single‐nucleotide polymorphisms (SNPs) and provided for the development of polygenic risk scores (PRS) to measure total genetic susceptibility. This review reviews the present evidence of SNPs in connection with CAD risk, discusses biological mechanisms whereby genetic variation affects vascular and metabolic phenotypes, and provides some methodological advances and limitations in PRS construction and testing. Although PRS extends risk stratification beyond clinical factors, its clinical utility is limited by population‐level effects, limited biological interpretability, and variable predictive performance. Furthermore, we also discuss new approaches incorporating genetically informed risk assessment into clinical and imaging‐based schemes to aid precision prevention. By explicitly bridging genetic association, biological interpretabilities, and clinical support, we aim to encourage responsible translation of genetic risk stratifying into CAD prevention.</jats:p>","journal":"Precision Medical Sciences","year":2026,"id":639575,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1661803,"name":"Mosi Chen","orcid":null,"position":1,"is_corresponding":false},{"id":230565,"name":"Jun Hu","orcid":"0000-0001-7098-6272","position":2,"is_corresponding":false},{"id":286449,"name":"Lei Huang","orcid":"0000-0003-4236-1448","position":3,"is_corresponding":false},{"id":1008275,"name":"Ye Yang","orcid":"0000-0001-7711-2121","position":4,"is_corresponding":false},{"id":7113,"name":"Chang Chen","orcid":"0000-0003-2841-1250","position":5,"is_corresponding":false},{"id":1661804,"name":"Ying Zhuang","orcid":null,"position":6,"is_corresponding":false},{"id":1373402,"name":"Yan Pan","orcid":"0000-0001-7277-6877","position":7,"is_corresponding":false},{"id":1661805,"name":"Bingjun Qian","orcid":null,"position":8,"is_corresponding":false},{"id":760878,"name":"Li Dai","orcid":"0000-0002-6306-1316","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Single‐nucleotide polymorphisms in coronary artery disease: Biological complexity, risk architecture, and implications for precision prevention","abstract":"<jats:title>Abstract</jats:title>\n                  <jats:p>Coronary artery disease (CAD) is characterized by significant genetic diversity with interindividual genetic variation. Genomewide association studies have discovered many CAD‐associated single‐nucleotide polymorphisms (SNPs) and provided for the development of polygenic risk scores (PRS) to measure total genetic susceptibility. This review reviews the present evidence of SNPs in connection with CAD risk, discusses biological mechanisms whereby genetic variation affects vascular and metabolic phenotypes, and provides some methodological advances and limitations in PRS construction and testing. Although PRS extends risk stratification beyond clinical factors, its clinical utility is limited by population‐level effects, limited biological interpretability, and variable predictive performance. Furthermore, we also discuss new approaches incorporating genetically informed risk assessment into clinical and imaging‐based schemes to aid precision prevention. By explicitly bridging genetic association, biological interpretabilities, and clinical support, we aim to encourage responsible translation of genetic risk stratifying into CAD prevention.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19910364","pmcid":null,"openalex_id":"https://openalex.org/W7140173529","authors":[],"funders":[{"funder_name":"National Natural Science Foundation of China","grant_id":"82200426","title":null}],"total_grants":1,"fwci":0.0,"citation_percentile":0.33668817,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://doi.org/10.1002/prm2.70031","host_type":"journal"},{"url":"https://doi.org/10.1002/prm2.70031","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/prm2.70031","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/full-xml/10.1002/prm2.70031","host_type":"publisher"}],"fields_of_study":["Genetic Associations and Epidemiology","BRCA gene mutations in cancer","Cardiac Imaging and Diagnostics"],"mesh_terms":[],"keywords":["Risk stratification","Genetic association","Genome-wide association study","Genetic variation","Coronary artery disease","Single-nucleotide polymorphism","Precision medicine","Disease","Risk assessment"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-07T00:52:05.389727Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}