{"doi":"10.1002/prca.202200031","title":"Plasma biomarkers for systemic inflammation in COVID‐19 survivors","abstract":"BACKGROUND: While the majority of COVID-19 patients fully recover from the infection and become asymptomatic, a significant proportion of COVID-19 survivors experience a broad spectrum of symptoms lasting weeks to months post-infection, a phenomenon termed \"post-acute sequelae of COVID-19 (PASC).\" The aim of this study is to determine whether inflammatory proteins are dysregulated and can serve as potential biomarkers for systemic inflammation in COVID-19 survivors. METHODS: We determined the levels of inflammatory proteins in plasma from 22 coronavirus disease 2019 (COVID-19) long haulers (COV-LH), 22 COVID-19 asymptomatic survivors (COV-AS), and 22 healthy subjects (HS) using an Olink proteomics assay and assessed the results by a beads-based multiplex immunoassay. RESULTS: Compared to HS, we found that COVID-19 survivors still exhibited systemic inflammation, as evidenced by significant changes in the levels of multiple inflammatory proteins in plasma from both COV-LH and COV-AS. CXCL10 was the only protein that significantly upregulated in COV-LH compared with COV-AS and HS. CONCLUSIONS: Our results indicate that several inflammatory proteins remain aberrantly dysregulated in COVID-19 survivors and CXCL10 might serve as a potential biomarker to typify COV-LH. Further characterization of these signature inflammatory molecules might improve the understanding of the long-term impacts of COVID-19 and provide new targets for the diagnosis and treatment of COVID-19 survivors with PASC.","journal":"PROTEOMICS - CLINICAL APPLICATIONS","year":2022,"id":236862,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":65,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9603,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":336311,"name":"Madison Schank","orcid":"0000-0001-9017-3180","position":1,"is_corresponding":false},{"id":336313,"name":"Ling Wang","orcid":"0000-0001-7861-2769","position":2,"is_corresponding":false},{"id":338131,"name":"Xindi Dang","orcid":null,"position":3,"is_corresponding":false},{"id":336315,"name":"Dechao Cao","orcid":"0000-0001-5038-1807","position":4,"is_corresponding":false},{"id":336317,"name":"Sushant Khanal","orcid":"0000-0001-8028-6034","position":5,"is_corresponding":false},{"id":336316,"name":"Lam Nhat Nguyen","orcid":"0000-0002-8419-8354","position":6,"is_corresponding":false},{"id":103949,"name":"Yi Zhang","orcid":"0000-0001-9861-4681","position":7,"is_corresponding":false},{"id":338133,"name":"Xiao Y. Wu","orcid":null,"position":8,"is_corresponding":false},{"id":652466,"name":"James L. Adkins","orcid":null,"position":9,"is_corresponding":false},{"id":857952,"name":"Benjamin Pelton","orcid":"0009-0000-1101-0966","position":10,"is_corresponding":false},{"id":336321,"name":"Jinyu Zhang","orcid":"0000-0003-1724-2367","position":11,"is_corresponding":false},{"id":336322,"name":"Shunbin Ning","orcid":"0000-0001-5484-5779","position":12,"is_corresponding":false},{"id":338135,"name":"Mohamed El Gazzar","orcid":null,"position":13,"is_corresponding":false},{"id":336323,"name":"Jonathan P. Moorman","orcid":"0000-0002-6102-6541","position":14,"is_corresponding":false},{"id":336324,"name":"Zhi Q. Yao","orcid":"0000-0002-1848-1071","position":15,"is_corresponding":false},{"id":336312,"name":"Juan Zhao","orcid":"0000-0002-1809-3124","position":0,"is_corresponding":true}],"reference_count":53,"raw_metadata":null,"created_at":"2026-07-19T00:22:03.686498Z","pmid":"35929818","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}