{"doi":"10.1002/prac.19863280209","title":"4‐Acyl‐2‐acylamino‐4,5‐dihydro‐1,3,4‐thiadiazole durch Acylierung von Thiosemicarbazonen","abstract":"<jats:p><jats:bold>4‐Acyl‐2‐acylamino‐4,5‐dihydro‐1,3,4‐thiadiazoles by Acylation of Thiosemicarbazones</jats:bold></jats:p><jats:p>Thiosemicarbazones and acid anhydrides or halides react to 4‐acyl‐2‐acylamino‐4,5‐dihydro‐1,3,4‐thiadiazoles (<jats:bold>2a</jats:bold>–<jats:bold>2v</jats:bold>) in high yields. 3‐Acyl‐2‐amino‐4,5‐dihydro‐1,3,4‐thiadiazoles <jats:bold>5</jats:bold> are proved as intermediates in this conversion. In special cases they can be isolated or submitted to further acylation with an other acylating agent. <jats:sup>1</jats:sup>H‐n.m.r., <jats:sup>13</jats:sup>C‐n.m.r. and mass spectroscopic data of compounds <jats:bold>2a</jats:bold>–<jats:bold>2v</jats:bold> and <jats:bold>5a</jats:bold>–<jats:bold>5e</jats:bold> are given. The preparation of the compounds <jats:bold>2</jats:bold> can also be carried out starting with a carbonyl compound and thiosemicarbazide without isolation of the thiosemicarbazone.</jats:p>","journal":"Journal für Praktische Chemie","year":1986,"id":41570,"datarank":2.510083386763762,"base_score":2.995732273553991,"endowment":2.995732273553991,"self_citation_contribution":0.4493598410330987,"citation_network_contribution":2.0607235457306636,"self_endowment_contribution":0.4493598410330987,"citer_contribution":2.0607235457306636,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":18,"citers_with_citation_signal":16,"citers_with_endowment":16,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":200074,"name":"Ernst Schmitz","orcid":null,"position":1,"is_corresponding":false},{"id":200075,"name":"Helmuth Seeboth","orcid":null,"position":2,"is_corresponding":false},{"id":200073,"name":"Siegfried Andreae","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.995732273553991,"endowment":2.995732273553991,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"18998881","pmcid":null,"openalex_id":"https://openalex.org/W2049397839","authors":[],"funders":[],"total_grants":0,"fwci":1.1534,"citation_percentile":0.73494106,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2023,"count":1},{"year":2024,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fprac.19863280209","host_type":"publisher"},{"url":"https://onlinelibrary.wiley.com/doi/pdf/10.1002/prac.19863280209","host_type":"publisher"},{"url":"https://doi.org/10.1002/prac.19863280209","host_type":"journal"}],"fields_of_study":["Synthesis and biological activity","Synthesis and Characterization of Heterocyclic Compounds","Structural and Chemical Analysis of Organic and Inorganic Compounds","Chemistry"],"mesh_terms":[],"keywords":["Acylation","Thiadiazoles","Chemistry","Semicarbazone","Halide","Acyl chloride","Acyl group","Stereochemistry","Medicinal chemistry","Organic chemistry","Group (periodic table)","Catalysis"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-13T02:28:51.715597Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}