{"doi":"10.1002/ppul.71319","title":"Asthma Phenotype Progression in Children and Adolescents: A Single Center Experience","abstract":"BACKGROUND: Asthma phenotype has implications for presentation and treatment selection. METHODS: This was a retrospective study of patients attending a pediatric pulmonary clinic (2009-2015) with EHR data available for phenotyping (allergic, eosinophilic/non-allergic or non-allergic/non-eosinophilic). Patients were classified by age. A multinomial regression model examined factors associated with phenotype. A logistic regression model examined factors associated with a change in phenotype (present/absent). RESULTS: There were 2042 patients included. Approximately 44% of participants were allergic, 17% eosinophilic/non-allergic and 39% non-allergic/non-eosinophilic. Among children 0-4 years, age of asthma onset (aOR 1.42, 95% CI 1.21, 1.65) and mean exacerbations (aOR 1.26 95% CI 1.09, 1.44) were associated with higher odds of an allergic phenotype (vs. non-allergic/non-eosinophilic). Among those aged 5-11 and 12-21, male sex and mild obstruction were positively associated, and age was negatively associated, with an allergic phenotype. Moderate/severe obstruction on spirometry (aOR 6.67, 95% CI 2.00, 22.29) and smoke exposure (aOR 1.77, 95% CI 1.17, 2.67) were also positively associated with an allergic phenotype in patients 12-21 years. Factors positively associated with a change in phenotype included index phenotype (eosinophilic/non-allergic: aOR 5.31, 95% CI 3.46, 8.14) and mean exacerbations (aOR 1.34, 95% CI 1.16, 1.55) (n = 1379). The allergic phenotype was most stable (> 95% predicted probability of remaining allergic); an eosinophilic/non-allergic phenotype had the greatest predicted probability of change (48%). CONCLUSIONS: Factors associated with asthma phenotype vary by age. The allergic phenotype was the most stable, while an eosinophilic/non-allergic phenotype was most prone to change.","journal":"Pediatric Pulmonology","year":2025,"id":578071,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9274,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1488135,"name":"Stephanie Shi","orcid":null,"position":1,"is_corresponding":false},{"id":491990,"name":"Yin Zhang","orcid":"0000-0002-6127-7535","position":2,"is_corresponding":false},{"id":801127,"name":"Md Monir Hossain","orcid":"0009-0002-9767-6711","position":3,"is_corresponding":false},{"id":317019,"name":"Theresa W. Guilbert","orcid":"0000-0002-6932-712X","position":4,"is_corresponding":false},{"id":383888,"name":"Christine L. Schuler","orcid":"0000-0001-9329-9459","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-19T02:58:20.638044Z","pmid":"41090234","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}