{"doi":"10.1002/ppul.71226","title":"Lung Function in a Multiethnic U.S. Cohort of Adolescents and Adults Born Preterm in the New BPD Era","abstract":"RATIONALE: Extreme preterm birth is a recognized risk factor for reduced pulmonary function over the lifespan. However, data are lacking in U.S.-born adults and in multiethnic populations. OBJECTIVE: To comprehensively evaluate lung function in adolescents and young adults born premature, and to assess for potential impact of neonatal, racial/ethnic, and socioeconomic risk factors on long-term lung function. METHODS: Preterm participants aged 12-40 years of age were recruited from the Parkland Hospital Neonatal ICU Registry (Dallas County, Texas). Preterm and term-born participants completed pulmonary function testing including spirometry, lung volumes, diffusion capacity, and respiratory muscle forces, using Global Lung Initiative race-neutral reference equations. Influence of racial/ethnic background, neonatal factors, and socioeconomic ratings were assessed for preterm participants. RESULTS: Preterm participants (n = 105; gestational age 29.5 ± 2.5 weeks; current age 26 ± 6 yrs) were significantly more likely than term participants (n = 48; gestational age 39.2 ± 1.1 weeks; current age 29 ± 7 yrs) to have an obstructive or restrictive ventilatory defect (34.4% vs 14.6%, OR 3.06, 95% CI 1.26-7.93), reduced diffusion capacity (16.4% vs 2.1%, OR 9.18, 95% CI 1.47-98.3), and impaired respiratory muscle strength (27.7% vs 4.4%, OR 8.22, 95% CI 2.10-36.2). Neonatal risk factors included history of bronchopulmonary dysplasia and lower weight for gestational age percentile. Lung function was worse in preterm-born Non-Hispanic Black participants compared to preterm-born Hispanic White participants, which could not be explained by available neonatal or socioeconomic factors. CONCLUSION: While most moderately to extremely preterm-born individuals have normal lung function, obstructive and restrictive ventilatory defects, reduced diffusion capacity, and impaired respiratory muscle strength are common.","journal":"Pediatric Pulmonology","year":2025,"id":526484,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8094,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":693798,"name":"Tyler J. Wall","orcid":"0000-0002-9506-6162","position":1,"is_corresponding":false},{"id":416370,"name":"Gregory P. Barton","orcid":"0000-0001-7471-5488","position":2,"is_corresponding":false},{"id":421485,"name":"D. Merrill Dane","orcid":null,"position":3,"is_corresponding":false},{"id":257959,"name":"Connie C. W. Hsia","orcid":"0000-0003-1995-1407","position":4,"is_corresponding":false},{"id":416371,"name":"Kara N. Goss","orcid":"0000-0003-2015-9169","position":5,"is_corresponding":false},{"id":1246064,"name":"Nataly J. Sanchez‐Solano","orcid":"0000-0002-4651-6016","position":0,"is_corresponding":true}],"reference_count":48,"raw_metadata":null,"created_at":"2026-07-19T02:50:30.402772Z","pmid":"40778641","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}