{"doi":"10.1002/ppul.25610","title":"Association of time of first corticosteroid treatment with bronchopulmonary dysplasia in preterm infants","abstract":"OBJECTIVE: To evaluate the association between the time of first systemic corticosteroid initiation and bronchopulmonary dysplasia (BPD) in preterm infants. STUDY DESIGN: A multi-center retrospective cohort study from January 2010 to December 2016 using the Children's Hospitals Neonatal Database and Pediatric Health Information System database was conducted. The study population included preterm infants <32 weeks' gestation treated with systemic corticosteroids after 7 days of age and before 34 weeks' postmenstrual age. Stepwise multivariable logistic regression was used to assess the association between timing of corticosteroid initiation and the development of Grade 2 or 3 BPD as defined by the 2019 Neonatal Research Network criteria. RESULTS: We identified 598 corticosteroid-treated infants (median gestational age 25 weeks, median birth weight 760 g). Of these, 47% (280 of 598) were first treated at 8-21 days, 25% (148 of 598) were first treated at 22-35 days, 14% (86 of 598) were first treated at 36-49 days, and 14% (84 of 598) were first treated at >50 days. Infants first treated at 36-49 days (aOR 2.0, 95% CI 1.1-3.7) and >50 days (aOR 1.9, 95% CI 1.04-3.3) had higher independent odds of developing Grade 2 or 3 BPD when compared to infants treated at 8-21 days after adjusting for birth characteristics, admission characteristics, center, and co-morbidities. CONCLUSIONS: Among preterm infants treated with systemic corticosteroids in routine clinical practice, later initiation of treatment was associated with a higher likelihood to develop Grade 2 or 3 BPD when compared to earlier treatment.","journal":"Pediatric Pulmonology","year":2021,"id":181364,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":16,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5453,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":463682,"name":"Joanne Lagatta","orcid":"0000-0002-5147-2396","position":1,"is_corresponding":false},{"id":368902,"name":"Rashmin C. Savani","orcid":"0000-0002-9533-5422","position":2,"is_corresponding":false},{"id":601081,"name":"Shilpa Vyas‐Read","orcid":"0000-0002-9402-6433","position":3,"is_corresponding":false},{"id":463686,"name":"William A. Engle","orcid":"0000-0003-4895-9731","position":4,"is_corresponding":false},{"id":463687,"name":"Rebecca S. Rose","orcid":"0000-0002-2533-9508","position":5,"is_corresponding":false},{"id":320044,"name":"Robert DiGeronimo","orcid":"0000-0001-6011-012X","position":6,"is_corresponding":false},{"id":728832,"name":"J. Wells Logan","orcid":"0000-0001-6929-704X","position":7,"is_corresponding":false},{"id":530639,"name":"Michel Mikhael","orcid":"0000-0001-8307-6569","position":8,"is_corresponding":false},{"id":470052,"name":"Girija Natarajan","orcid":"0000-0003-0464-771X","position":9,"is_corresponding":false},{"id":239391,"name":"William E. Truog","orcid":null,"position":10,"is_corresponding":false},{"id":732192,"name":"Matthew J. Kielt","orcid":"0000-0002-4568-9070","position":11,"is_corresponding":false},{"id":463683,"name":"Karna Murthy","orcid":"0000-0003-3363-9663","position":12,"is_corresponding":false},{"id":463684,"name":"Isabella Zaniletti","orcid":"0000-0003-1234-3468","position":13,"is_corresponding":false},{"id":695502,"name":"Tamorah Lewis","orcid":"0000-0003-2137-8339","position":14,"is_corresponding":false},{"id":732191,"name":"Alain Cuna","orcid":"0000-0002-8174-4487","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-18T23:48:05.146883Z","pmid":"34379886","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}