{"doi":"10.1002/pmic.202100145","title":"Progress in methodologies and quality‐control strategies in protein cross‐linking mass spectrometry","abstract":"Deciphering the interaction networks and structural dynamics of proteins is pivotal to better understanding their biological functions. Cross-linking mass spectrometry (XL-MS) is a powerful and increasingly popular technology that provides information about protein-protein interactions and their structural constraints for individual proteins and multiprotein complexes on a proteome-scale. In this review, we first assess the coverage and depth of the XL-MS technique by utilizing publicly available datasets. We then delve into the progress in XL-MS experimental and computational methodologies and examine different quality-control strategies reported in the literature. Finally, we discuss the progress in XL-MS applications along with the scope for future improvements.","journal":"PROTEOMICS","year":2021,"id":193347,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9372,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":670739,"name":"Qiuye Zhao","orcid":"0000-0002-4009-9944","position":1,"is_corresponding":false},{"id":762482,"name":"Shobhita Gupta","orcid":null,"position":2,"is_corresponding":false},{"id":670737,"name":"Dapeng Xiong","orcid":"0000-0002-8381-5680","position":3,"is_corresponding":false},{"id":268021,"name":"Haiyuan Yu","orcid":"0000-0001-7597-6049","position":4,"is_corresponding":false},{"id":571516,"name":"Kumar Yugandhar","orcid":"0000-0003-1141-4439","position":0,"is_corresponding":true}],"reference_count":171,"raw_metadata":null,"created_at":"2026-07-18T23:49:51.300073Z","pmid":"34647422","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}