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In this review, we will explore factors that impact galectin activity, including the effect of glycan modification on galectin–glycan interactions.</jats:p>","journal":"PROTEOMICS","year":2016,"id":592259,"datarank":2.3542031670467227,"base_score":4.442651256490317,"endowment":4.442651256490317,"self_citation_contribution":0.6663976884735476,"citation_network_contribution":1.687805478573175,"self_endowment_contribution":0.6663976884735476,"citer_contribution":1.687805478573175,"corpus_percentile":null,"corpus_rank":null,"citation_count":84,"citer_count":66,"citers_with_citation_signal":60,"citers_with_endowment":60,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":226163,"name":"Connie M. 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Among protein–ligand pairs, glycan binding proteins (GBPs) and the glycans they recognize represent unique and highly complex interactions implicated in a broad range of regulatory activities. With few exceptions, cell surface receptors and secreted proteins are heavily glycosylated. As these glycans often represent highly regulatable post‐translational modifications, alterations in glycosylation can fundamentally impact GBP recognition. Among GBPs, galectins in particular appear to engage a diverse set of glycan determinants to impact a broad range of biological processes. In this review, we will explore factors that impact galectin activity, including the effect of glycan modification on galectin–glycan interactions.</jats:p>","is_dataset_classified":null,"base_score":4.442651256490317,"endowment":4.442651256490317,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27582340","pmcid":"PMC5832938","openalex_id":"https://openalex.org/W2515567810","authors":[],"funders":[{"funder_name":"NIH HHS","grant_id":"DP5 OD019892","title":null},{"funder_name":"NIGMS NIH HHS","grant_id":"T32 GM008169","title":null}],"total_grants":2,"fwci":1.973,"citation_percentile":0.85960561,"influential_citations":0,"citation_trend":[{"year":2017,"count":2},{"year":2018,"count":4},{"year":2019,"count":8},{"year":2020,"count":15},{"year":2021,"count":12},{"year":2022,"count":19},{"year":2023,"count":6},{"year":2024,"count":4},{"year":2025,"count":10},{"year":2026,"count":4}],"oa_status":"green","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5832938","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5832938","host_type":"repository"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpmic.201600116","host_type":"publisher"},{"url":"https://analyticalsciencejournals.onlinelibrary.wiley.com/doi/pdf/10.1002/pmic.201600116","host_type":"publisher"},{"url":"https://doi.org/10.1002/pmic.201600116","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27582340","host_type":"repository"}],"fields_of_study":["Galectins and Cancer Biology","Signaling Pathways in Disease","Peptidase Inhibition and Analysis"],"mesh_terms":["Amino Acid Sequence","Animals","Blood Group Antigens","Carbohydrate Sequence","Chromatography, Affinity","Glycolipids","Humans","Ligands","Polysaccharides","Protein Binding","Protein Processing, Post-Translational","Galectins","Molecular Docking Simulation"],"keywords":["Galectin","Glycan","Glycosylation","Computational biology","Cell biology","Biology","Receptor","Chemistry","Biochemistry","Glycoprotein","Surface plasmon resonance","frontal affinity chromatography","glycoproteomics","Glycan Binding Protein"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[{"name":"pdb"}],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-26T12:55:02.380225Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}