{"doi":"10.1002/ped4.12450","title":"Design and implementation of a multicenter protocol to obtain impulse oscillometry data in preterm children","abstract":"Importance: Objective measures of lung function are critical for assessing respiratory outcomes of prematurity. Among extremely low gestational age neonates (ELGANs) (< 29 weeks gestational age), high rates of neurodevelopmental impairment may interfere with lung function testing. Impulse oscillometry (IOS) is a noninvasive test of respiratory system mechanics not requiring forced expiration. Objective: To describe a multicenter study design for respiratory follow-up testing in a cohort with a high rate of extreme prematurity. Methods: School-age children enrolled in two prior trials of ELGANs and term controls were assessed by IOS at five centers. Groups consisted of children with prematurity with a high incidence of bronchopulmonary dysplasia, children with prematurity with no or minimal lung disease, and healthy term children. A rigorous centralized review process reviewed IOS studies for technical acceptability. Approach to design and implementation, rates of feasibility and success, and characteristics of participants are described. Results: A total of 243 children were recruited, of whom 239 (98%) attempted oscillometry. There were high rates of technical acceptability across all three cohorts (85%-90% of attempted tests), and across all five centers (80%-94% of attempted tests). Respiratory and neuromotor clinical factors associated with testing failure included a higher number of days on ventilation during neonatal intensive care, a history of intraventricular hemorrhage grade 3 or 4, and gross motor functional impairment. Interpretation: We report high rates of feasibility and success of oscillometry in a large multicenter ELGAN population, in whom neurological and developmental comorbidities likely play a confounding role.","journal":"Pediatric Investigation","year":2024,"id":469293,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9354,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":571706,"name":"Clement L. Ren","orcid":"0000-0003-4431-0644","position":1,"is_corresponding":false},{"id":1136891,"name":"Julian L. Allen","orcid":"0000-0003-0949-0010","position":2,"is_corresponding":false},{"id":388541,"name":"Carla Bann","orcid":"0000-0001-9305-8305","position":3,"is_corresponding":false},{"id":384582,"name":"Joseph M. McDonough","orcid":null,"position":4,"is_corresponding":false},{"id":1303036,"name":"Kristina Ziolkowski","orcid":null,"position":5,"is_corresponding":false},{"id":572133,"name":"Charles Clem","orcid":null,"position":6,"is_corresponding":false},{"id":355528,"name":"Sara B. DeMauro","orcid":"0000-0003-1647-4000","position":7,"is_corresponding":false},{"id":900684,"name":"Katharine Tsukahara","orcid":"0000-0003-2115-5944","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T02:05:28.027781Z","pmid":"39720285","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}