{"doi":"10.1002/pds.5863","title":"Lack of Evidence for Vaccine‐Associated Enhanced Disease From <scp>COVID</scp>‐19 Vaccines Among Adults in the Vaccine Safety Datalink","abstract":"PURPOSE: Vaccine-associated enhanced disease (VAED) is a theoretical concern with new vaccines, although trials of authorized vaccines against SARS-CoV-2 have not identified markers for VAED. The purpose of this study was to detect any signals for VAED among adults vaccinated against coronavirus disease 2019 (COVID-19). METHODS: In this cross-sectional study, we assessed COVID-19 severity as a proxy for VAED among 400 adults hospitalized for COVID-19 from March through October 2021 at eight US healthcare systems. Primary outcomes were admission to an intensive care unit (ICU) and severe illness (score ≥6 on the World Health Organization [WHO] Clinical Progression Scale). We compared the risk of outcomes among those who had completed a COVID-19 vaccine primary series versus those who were unvaccinated. We incorporated inverse propensity weights for vaccination status in a doubly robust regression model to estimate the causal average treatment effect. RESULTS: The causal risk ratio in vaccinated versus unvaccinated was 0.36 (95% confidence interval [CI], 0.15-0.94) for ICU admission and 0.46 (95% CI, 0.25-0.76) for severe illness. CONCLUSION: Among hospitalized patients, reduced disease severity in those vaccinated against COVID-19 supports the absence of VAED.","journal":"Pharmacoepidemiology and Drug Safety","year":2024,"id":468875,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8855,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":360568,"name":"David L. McClure","orcid":"0000-0001-8470-7190","position":1,"is_corresponding":false},{"id":105911,"name":"Kayla E. Hanson","orcid":"0009-0004-5117-8279","position":2,"is_corresponding":false},{"id":371264,"name":"Matthew F. Daley","orcid":"0000-0003-1309-4096","position":3,"is_corresponding":false},{"id":371262,"name":"Malini B. DeSilva","orcid":"0000-0003-3705-1672","position":4,"is_corresponding":false},{"id":371265,"name":"Stephanie A. Irving","orcid":"0000-0001-7437-6797","position":5,"is_corresponding":false},{"id":218071,"name":"Lisa A. Jackson","orcid":"0000-0002-1785-0218","position":6,"is_corresponding":false},{"id":360572,"name":"Nicola P. Klein","orcid":"0000-0003-1777-4814","position":7,"is_corresponding":false},{"id":740004,"name":"Bruno Lewin","orcid":"0000-0003-1483-2791","position":8,"is_corresponding":false},{"id":1301902,"name":"J. Williams","orcid":"0000-0001-7177-6170","position":9,"is_corresponding":false},{"id":330739,"name":"Jonathan Duffy","orcid":"0000-0002-8060-0940","position":10,"is_corresponding":false},{"id":330737,"name":"Michael M. McNeil","orcid":"0000-0003-0713-8312","position":11,"is_corresponding":false},{"id":360574,"name":"Eric Weintraub","orcid":"0000-0003-0375-0504","position":12,"is_corresponding":false},{"id":105912,"name":"Edward A. Belongia","orcid":"0000-0001-7478-0415","position":13,"is_corresponding":false},{"id":382544,"name":"Thomas G. Boyce","orcid":"0000-0002-9579-6982","position":0,"is_corresponding":true}],"reference_count":19,"raw_metadata":null,"created_at":"2026-07-19T02:05:23.500722Z","pmid":"39155049","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}