{"doi":"10.1002/pd.6319","title":"Fetal surgery is not associated with increased inflammatory placental pathology","abstract":"OBJECTIVE: Fetal surgery has improved neonatal outcomes; however, it is unknown if the intervention contributes to the developmental of inflammatory pathologies in the placenta. Here, an association between fetal surgery and placental pathology was examined. METHOD: This case-control study compared pregnancies with fetal surgery (n = 22), pregnancies with an indication for fetal surgery but without an intervention being done (n = 13), and gestational-age and fetus-number matched controls (n = 36). Data on maternal, infant, and placental outcomes were abstracted. Additionally, immunohistochemistry identified expression of lymphoid and myeloid cells in the placenta on a subset of cases. Comparisons were performed using Kruskal-Wallis or Pearson's chi-squared tests. RESULTS: Maternal characteristics were comparable between groups. Most fetal interventions were for diaphragmatic hernia, spina bifida, or twin-to-twin transfusion syndrome. Fetuses who were operated on before birth were more likely to be born preterm (p = 0.02). There was no increase in the rate of observed placental pathologies or immune cell infiltration in fetal surgery cases compared to controls. CONCLUSION: The data suggest that fetal surgery is not associated with increased inflammatory or morphologic pathology in the placenta. This observation supports the growing field of fetal surgery.","journal":"Prenatal Diagnosis","year":2023,"id":382984,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9408,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1150248,"name":"E. Heidi Cheek‐Norgan","orcid":null,"position":1,"is_corresponding":false},{"id":406174,"name":"Megan E. Branda","orcid":"0000-0003-0779-6876","position":2,"is_corresponding":false},{"id":905072,"name":"Andrew P. Norgan","orcid":"0000-0002-2955-2066","position":3,"is_corresponding":false},{"id":1149885,"name":"Mauro Schenone","orcid":"0000-0002-2118-4852","position":4,"is_corresponding":false},{"id":291734,"name":"Maureen A. Lemens","orcid":"0000-0001-9311-4207","position":5,"is_corresponding":false},{"id":236026,"name":"Rana Chakraborty","orcid":"0000-0002-6585-0087","position":6,"is_corresponding":false},{"id":236024,"name":"Rodrigo Ruano","orcid":"0000-0002-3642-5858","position":7,"is_corresponding":false},{"id":236020,"name":"Elizabeth Ann L. Enninga","orcid":"0000-0003-3621-7335","position":8,"is_corresponding":false},{"id":1058249,"name":"María C. Cárdenas","orcid":"0000-0003-4166-5378","position":0,"is_corresponding":true}],"reference_count":33,"raw_metadata":null,"created_at":"2026-07-19T01:17:25.158896Z","pmid":"36688485","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}