{"doi":"10.1002/pd.4313","title":"Effect of smoking status on inhibin‐A in second‐trimester prenatal screening for Down syndrome","abstract":"<jats:p><jats:bold>What's already known about this topic?</jats:bold>  \n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>Inhibin‐A is a useful marker in screening for Down syndrome in the second trimester of pregnancy.</jats:p></jats:list-item>\n<jats:list-item><jats:p>It is known to be about 50% higher among women who state they smoke compared with women who state they do not smoke.</jats:p></jats:list-item>\n<jats:list-item><jats:p>A single adjustment factor has been used in antenatal screening programmes.</jats:p></jats:list-item></jats:list></jats:p><jats:p><jats:bold>What does this study add?</jats:bold>  \n<jats:list list-type=\"bullet\">\n<jats:list-item><jats:p>This study shows that the extent of the effect of smoking on Inhibin‐A is dependent on the gestational age of the pregnancy.</jats:p></jats:list-item>\n<jats:list-item><jats:p>The extent of the effect increases from about 20% higher at early gestation (14 weeks) to about 70% higher at later gestations (20 weeks).</jats:p></jats:list-item>\n<jats:list-item><jats:p>An equation allowing the effect of gestation to be considered is presented.</jats:p></jats:list-item></jats:list></jats:p>","journal":"Prenatal Diagnosis","year":2014,"id":617433,"datarank":0.23846904082925108,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.07367719752903462,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.07367719752903462,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":2,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1592319,"name":"Jonathan Bestwick","orcid":null,"position":1,"is_corresponding":false},{"id":1548616,"name":"Nicholas Wald","orcid":null,"position":2,"is_corresponding":false},{"id":1592317,"name":"Wayne Huttly","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-08-03T01:42:29.251335Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}