{"doi":"10.1002/pbc.31942","title":"Empowering Minds: A Pilot Study to Assess Feasibility of ADAPT‐SCD to Enhance Cognitive Function in Adolescents and Young Adults With Sickle Cell Disease","abstract":"BACKGROUND: Executive functioning (EF) deficits are a well-documented complication of sickle cell disease (SCD), yet no standard intervention exists to address this issue. Adapting Daily Activity Performance Through Strategy Training (ADAPT) is a metacognitive strategy training protocol designed to enhance self-assessment and strategic problem-solving, showing potential to mitigate EF deficits in individuals with SCD. PROCEDURE: Adolescents and young adults (AYA) aged 16-25 years with a documented SCD diagnosis were recruited. Baseline assessments of depression, self-awareness, and EF were conducted. Participants completed an adapted version of ADAPT, known as ADAPT-SCD, consisting of 10-14 sessions delivered either in person or via telehealth. Follow-up assessments were conducted immediately post-program and 6 months later. Feasibility was defined as 50% of approached AYA consenting and 10 participants completing at least 10 sessions. Acceptability was determined through participant responses in post-program interviews and surveys. A secondary aim was to examine the changes in EF and depression scores. RESULTS: Feasibility of ADAPT-SCD was partially supported, with 38% (19/50) of approached AYA enrolling, and 10 participants completing the required 10 sessions. Acceptability was supported through positive participant feedback on post-program surveys and interviews. While most changes in EF and depression measures were not clinically significant, the List Sorting Working Memory subtest of the National Institutes of Health Toolbox-Cognitive Battery showed a significant improvement. CONCLUSIONS: ADAPT-SCD demonstrated strong acceptability and partial feasibility. However, its impact on EF and depression outcomes warrants further investigation to establish clinical significance and inform future interventions for SCD-related cognitive challenges.","journal":"Pediatric Blood & Cancer","year":2025,"id":534388,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9618,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":390607,"name":"Elizabeth R. Skidmore","orcid":"0000-0002-8287-7193","position":1,"is_corresponding":false},{"id":426056,"name":"Taniya Varughese","orcid":"0000-0002-7300-6986","position":2,"is_corresponding":false},{"id":1280326,"name":"Abigail Picinich","orcid":null,"position":3,"is_corresponding":false},{"id":1280327,"name":"Nai Qashou","orcid":null,"position":4,"is_corresponding":false},{"id":1417497,"name":"Odaro Adu","orcid":null,"position":5,"is_corresponding":false},{"id":331324,"name":"Allison A. King","orcid":"0000-0002-1951-6176","position":6,"is_corresponding":false},{"id":1417496,"name":"Grace Hurley","orcid":null,"position":0,"is_corresponding":true}],"reference_count":43,"raw_metadata":null,"created_at":"2026-07-19T02:51:47.434742Z","pmid":"40781817","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}