{"doi":"10.1002/pbc.31856","title":"Evaluation of the Childhood Hodgkin International Prognostic Score (CHIPS) in High‐Risk Pediatric Hodgkin Lymphoma Patients Treated on Children's Oncology Group AHOD1331","abstract":"BACKGROUND: CHIPS (Childhood Hodgkin International Prognostic Score), a predictive score for event-free-survival (EFS), was originally developed using factors presenting at diagnosis in patients with intermediate-risk Hodgkin lymphoma (HL). Prospective validation of CHIPS in patients was a pre-specified aim of AHOD1331, a trial comparing brentuximab-vedotin, doxorubicin, vincristine, etoposide, prednisone, and cyclophosphamide (Bv-AVEPC) to standard ABVE-PC (and response-adapted radiation) in children with high-risk HL. METHODS: AHOD1331 was a multicenter randomized phase 3 study. Patients were aged 2-21 years with untreated stages IIB+bulk, IIIB, IV HL. CHIPS was determined by assigning one point each for: Stage IV disease, large mediastinal adenopathy (greater than one-third thoracic diameter), albumin (<3.5 g/dL), and fever (T ≥ 38°C). Associations between CHIPS, baseline patient, and disease characteristics were tested. The validity of CHIPS to predict EFS was evaluated by both overall and within pre-specified subgroups defined by treatment arm, PET2 response, and disease stage. RESULTS: The four CHIPS components were analyzable in 576 of the 587 eligible patients. Distribution of CHIPS did not differ by study treatment arm (p = 0.158). CHIPS was significantly prognostic for EFS in this high-risk cohort (p = 0.008) and was independently predictive of EFS regardless of treatment arm, PET2 response, or stage. In subset analyses, CHIPS remained independently prognostic among patients with PET2 rapid responding lesions (RRL; p = 0.021) or Stage IVB disease (p = 0.047). CONCLUSION: CHIPS were predictive of EFS in patients with high-risk HL treated on AHOD1331. CHIPS may aid in the allocation of patients to risk-based treatment algorithms, and can serve as an effective, inexpensive, and feasible proxy for more biologically based factors.","journal":"Pediatric Blood & Cancer","year":2025,"id":544788,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9476,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":381789,"name":"Lindsay A. Renfro","orcid":"0000-0002-4306-1896","position":1,"is_corresponding":false},{"id":843891,"name":"Frank G. Keller","orcid":"0009-0004-8919-467X","position":2,"is_corresponding":false},{"id":401866,"name":"David Hodgson","orcid":"0000-0003-4687-4582","position":3,"is_corresponding":false},{"id":559297,"name":"Angela Punnett","orcid":"0000-0003-4541-0823","position":4,"is_corresponding":false},{"id":458798,"name":"Kathleen M. McCarten","orcid":"0009-0002-2580-4171","position":5,"is_corresponding":false},{"id":458800,"name":"Steve Y. Cho","orcid":"0000-0003-2724-7778","position":6,"is_corresponding":false},{"id":1128781,"name":"Yue Wu","orcid":"0009-0005-8020-2650","position":7,"is_corresponding":false},{"id":321130,"name":"Kara M. Kelly","orcid":"0000-0003-1473-3937","position":8,"is_corresponding":false},{"id":282785,"name":"Sharon M. Castellino","orcid":"0000-0001-8367-2002","position":9,"is_corresponding":false},{"id":458799,"name":"Cindy L. Schwartz","orcid":"0000-0001-6269-021X","position":10,"is_corresponding":false},{"id":1084884,"name":"Jennifer A. Belsky","orcid":"0000-0002-2260-0395","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T02:53:17.418915Z","pmid":"40515508","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}