{"doi":"10.1002/pbc.31369","title":"Feasibility of telehealth exercise and nicotinamide riboside supplementation in survivors of childhood cancer at risk for diabetes: A pilot randomized controlled trial","abstract":"BACKGROUND: Childhood cancer survivors (CCS) have a 50% higher risk of diabetes mellitus (DM) compared with the general population. Interventions in survivors with prediabetes (fasting glucose 100-125 mg/dL or hemoglobin A1c 5.7%-6.4%) may mitigate the development of DM and its attendant morbidity, but there is limited information on the feasibility of secondary prevention in this setting. METHODS: This 6-week pilot feasibility 1:1 randomized controlled trial enrolled 20 CCS on a structured telehealth exercise program ± nicotinamide riboside (NR), a nicotinamide adenine dinucleotide precursor. Feasibility metrics were: (1) ≥50% of eligible CCS enrolled onto study; (2) ≥70% of participants completed baseline and end-of-study assessments; (3) ≥70% compliance with exercise and NR. Secondary endpoints included changes in biomarkers associated with glucose homeostasis and muscle health. RESULTS: Median age (years) at cancer diagnosis was 16.5 (range, 1.5-21.5) and 35.5 (range, 18.0-67.0) at study enrollment. Enrollment rate was 87%, and 85% of participants completed baseline and end-of-study assessments. The mean percentage of exercise sessions completed was 86.6%; NR compliance was > 90%. There were no severe adverse events attributable to study interventions. Secondary endpoints were not significantly different between study arms at study completion. Myostatin decrease was observed in participants who completed a higher median number of exercise sessions and was associated with decreased intramuscular adipose tissue and increased lower extremity muscle cross-sectional area. CONCLUSIONS: A telehealth exercise intervention ± NR supplementation was feasible in CCS with prediabetes. Future studies in larger cohorts may be needed to evaluate their beneficial effects on muscle health and DM risk among CCS.","journal":"Pediatric Blood & Cancer","year":2024,"id":477712,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1300403,"name":"Kara Lukas","orcid":"0000-0002-7273-1158","position":1,"is_corresponding":false},{"id":383612,"name":"Kyuwan Lee","orcid":"0000-0002-2015-4109","position":2,"is_corresponding":false},{"id":1316347,"name":"Justin Shamunee","orcid":null,"position":3,"is_corresponding":false},{"id":1316348,"name":"Barbosa Almeida","orcid":null,"position":4,"is_corresponding":false},{"id":1316349,"name":"Tati Guzman","orcid":null,"position":5,"is_corresponding":false},{"id":535121,"name":"Meagan Echevarria","orcid":"0000-0001-8181-410X","position":6,"is_corresponding":false},{"id":535833,"name":"Lanie Lindenfeld","orcid":null,"position":7,"is_corresponding":false},{"id":894151,"name":"Christian H. Nenninger","orcid":"0009-0008-7580-5328","position":8,"is_corresponding":false},{"id":535120,"name":"Aleksi Iukuridze","orcid":"0000-0001-9444-1939","position":9,"is_corresponding":false},{"id":1085868,"name":"Sophia Albanese","orcid":"0009-0004-0471-5668","position":10,"is_corresponding":false},{"id":242372,"name":"June‐Wha Rhee","orcid":"0000-0002-7044-2985","position":11,"is_corresponding":false},{"id":282277,"name":"Sitong Chen","orcid":"0000-0002-8975-7565","position":12,"is_corresponding":false},{"id":201107,"name":"Charles Brenner","orcid":"0000-0002-4955-3226","position":13,"is_corresponding":false},{"id":341507,"name":"F. Lennie Wong","orcid":"0000-0002-4333-5017","position":14,"is_corresponding":false},{"id":401865,"name":"Saro H. Armenian","orcid":"0000-0003-2604-8603","position":15,"is_corresponding":false},{"id":939852,"name":"Rusha Bhandari","orcid":"0000-0003-2069-1518","position":0,"is_corresponding":true}],"reference_count":61,"raw_metadata":null,"created_at":"2026-07-19T02:06:37.812633Z","pmid":"39387327","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}