{"doi":"10.1002/pbc.31320","title":"Feasibility and acceptability of a parent–child intervention to improve step count in childhood cancer survivors exposed to cardiotoxic therapy: The STEP UP for FAMILIES Study","abstract":"BACKGROUND: Late morbidity after childhood cancer may be mitigated by healthy lifestyle behaviors. We piloted a game-based, parent-child digital intervention to increase activity in sedentary survivors. METHODS: Survivors aged 10-16 treated with cardiotoxic therapy and not meeting US physical activity guidelines were enrolled in a single-arm study with a parent. Following a 14-day run-in, participants chose a prespecified step goal and wore an accelerometer daily for 24 weeks (12-week game-based intervention; 12-week follow-up). Participants completed the Acceptability of Intervention Measure (AIM) at 24 weeks; a subset of dyads completed qualitative interviews. RESULTS: Among 129 eligible survivors, 27 enrolled (20.9% participation rate) with a parent. Four dyads were removed during the 14-day run-in period due to noncompliance. Among the 23 dyads who continued to the study, the tracker was worn for 95% of days during the 12-week intervention (95% confidence interval [CI]: 94-96) and 81% during the 12-week follow-up (95% CI: 79-82). Overall, the prespecified step goal was met for 64% (95% CI: 63-66) of days during the intervention and 37% (95% CI: 35-38) during the follow-up. At the end of study, 17/23 dyads responded to AIM; 82% of survivors and 94% of parents reported the intervention as acceptable. During qualitative interviews (n = 5), dyads noted that they liked the accountability of the \"buddy system,\" but would have liked more personalized goal-setting. CONCLUSIONS: Despite high ratings of acceptability among participants, difficulties with sustained adherence and retention were encountered in this parent-child gamification intervention. Alternate, tailored designs should be considered in the future.","journal":"Pediatric Blood & Cancer","year":2024,"id":456508,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9472,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":268585,"name":"Jessica A. Lavery","orcid":"0000-0002-2746-5647","position":1,"is_corresponding":false},{"id":286118,"name":"Chaya S. Moskowitz","orcid":"0000-0002-2850-8450","position":2,"is_corresponding":false},{"id":1281864,"name":"I. Gordon","orcid":null,"position":3,"is_corresponding":false},{"id":1088588,"name":"Jaime Gilliland","orcid":"0009-0006-9944-3283","position":4,"is_corresponding":false},{"id":278746,"name":"Jessica M. Scott","orcid":"0000-0002-4845-5800","position":5,"is_corresponding":false},{"id":572111,"name":"Deborah Diotallevi","orcid":null,"position":6,"is_corresponding":false},{"id":572112,"name":"Elaine Pottenger","orcid":null,"position":7,"is_corresponding":false},{"id":572113,"name":"Nadia Wilson","orcid":null,"position":8,"is_corresponding":false},{"id":571654,"name":"Zoltan Antal","orcid":"0000-0001-8471-8930","position":9,"is_corresponding":false},{"id":1281382,"name":"Sameera Ramjan","orcid":"0000-0003-4311-5353","position":10,"is_corresponding":false},{"id":282356,"name":"Stephen A. Sands","orcid":"0000-0003-4550-263X","position":11,"is_corresponding":false},{"id":385622,"name":"Danielle Novetsky Friedman","orcid":"0000-0003-4668-9176","position":0,"is_corresponding":true}],"reference_count":57,"raw_metadata":null,"created_at":"2026-07-19T02:03:32.516678Z","pmid":"39285785","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}