{"doi":"10.1002/pbc.31169","title":"Episodes of acute methotrexate‐related neurotoxicity linked to compromised long‐term neurocognitive function","abstract":"Methotrexate is a critical component of curative chemotherapy for pediatric acute lymphoblastic leukemia (ALL), but is associated with neurotoxicity. Information on long-term outcomes following an acute neurotoxic event is limited. Therefore, this report compares neurocognitive performance more than 12 months post diagnosis (mean = 4 years) between ALL patients with (n = 25) and without (n = 146) a history of acute neurotoxicity. Compared to children with no documented on-treatment neurotoxic event, children who experienced a neurotoxic event during treatment exhibited poorer performance on measures of fine motor function (p = .02) and attention (p = .02). Children with ALL who experience acute neurotoxicity may be candidates for early neuropsychological screening and intervention.","journal":"Pediatric Blood & Cancer","year":2024,"id":454698,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.97,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":412852,"name":"Olga A. Taylor","orcid":null,"position":1,"is_corresponding":false},{"id":961111,"name":"Kimberly P. Raghubar","orcid":"0000-0002-9332-181X","position":2,"is_corresponding":false},{"id":1278603,"name":"Mariana Matheus Gonzalez","orcid":null,"position":3,"is_corresponding":false},{"id":762403,"name":"Mark Zobeck","orcid":"0000-0003-0997-906X","position":4,"is_corresponding":false},{"id":499122,"name":"M. Monica Gramatges","orcid":"0000-0002-0947-104X","position":5,"is_corresponding":false},{"id":247452,"name":"Karen R. Rabin","orcid":"0000-0002-4081-8195","position":6,"is_corresponding":false},{"id":247449,"name":"Michael E. Scheurer","orcid":"0000-0002-8379-6088","position":7,"is_corresponding":false},{"id":732258,"name":"Austin L. Brown","orcid":"0000-0001-5802-5073","position":8,"is_corresponding":false},{"id":967574,"name":"Rachel D. Harris","orcid":"0000-0002-8191-5477","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-19T02:03:12.720997Z","pmid":"38961583","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}