{"doi":"10.1002/pbc.30825","title":"Missing the mark? Exploratory analysis of the 10‐year‐old cutoff as an independent marker of high‐risk disease in pediatric B‐ALL","abstract":"This single-center, retrospective study evaluated age as a risk factor for relapsed/refractory disease and/or death in 153 children with B-cell acute lymphoblastic leukemia. The study sample included children near the 10-year age cutoff for high-risk disease (6.0-13.9 years at diagnosis) and without other high-risk features (high white cell count, unfavorable cytogenetics). Children 10.0-13.9 years treated per high-risk protocols did not have inferior outcomes compared with children aged 6.0-9.9 years initiating treatment per standard-risk protocols. The study indicates that, in the era of cytogenetics, an age threshold of 10 years might not be an independent prognostic marker. Multicenter analyses are needed.","journal":"Pediatric Blood & Cancer","year":2023,"id":415396,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.6964,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":378712,"name":"Nicholas P. DeGroote","orcid":"0009-0000-5056-1699","position":1,"is_corresponding":false},{"id":1197660,"name":"Michaela Henderson","orcid":null,"position":2,"is_corresponding":false},{"id":1197405,"name":"Katherine A. Jordan","orcid":"0000-0003-3458-1512","position":3,"is_corresponding":false},{"id":1197406,"name":"Christiana Ziworitin‐Ogola","orcid":"0009-0009-9485-0340","position":4,"is_corresponding":false},{"id":282785,"name":"Sharon M. Castellino","orcid":"0000-0001-8367-2002","position":5,"is_corresponding":false},{"id":378715,"name":"Tamara P. Miller","orcid":"0000-0003-4250-5376","position":6,"is_corresponding":false},{"id":1037871,"name":"Paul E. George","orcid":"0000-0002-7209-2827","position":0,"is_corresponding":true}],"reference_count":12,"raw_metadata":null,"created_at":"2026-07-19T01:22:12.933438Z","pmid":"38146039","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}