{"doi":"10.1002/path.1711650406","title":"Fibrinolysis and angiogenesis in wound healing","abstract":"<jats:title>Abstract</jats:title><jats:p>The healing wound offers a clear example of the sequence of events in chronic inflammation leading to repair. Although angiogenesis has an obvious and essential role in this process, it has been little studied. For an angiogenic factor to seem relevant, it would have to be shown to precede the peak of increased vascularity. To define this peak, the vessel content of simple, incised mouse wounds was estimated using morphometry of histological sections, and found to rise to a maximum at days 5 and 6. Total angiogenic activity of aqueous extracts was found to reach a peak at day 3. The detection of such activity on the chick chorioallantoic membrane is very dependent on the preparation technique and the choice of proteinase inhibitors. Previous <jats:italic>in vitro</jats:italic> work by us using purified material has shown fibrin degradation products to be effective in stimulating angiogenesis. Fibrin degradation products are prominent on immunoblotting from day 3, when macrophages are plentiful, with a similar band pattern to human granulation tissue.</jats:p>","journal":"The Journal of Pathology","year":1991,"id":38065,"datarank":5.935469685581273,"base_score":4.330733340286331,"endowment":4.330733340286331,"self_citation_contribution":0.6496100010429497,"citation_network_contribution":5.285859684538323,"self_endowment_contribution":0.6496100010429497,"citer_contribution":5.285859684538323,"corpus_percentile":null,"corpus_rank":null,"citation_count":75,"citer_count":66,"citers_with_citation_signal":61,"citers_with_endowment":61,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":188477,"name":"John A. Harvey","orcid":null,"position":1,"is_corresponding":false},{"id":189459,"name":"Majid A. Kazmi","orcid":null,"position":2,"is_corresponding":false},{"id":189460,"name":"Alistair J. Stout","orcid":null,"position":3,"is_corresponding":false},{"id":189458,"name":"W. Douglas Thompson","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.330733340286331,"endowment":4.330733340286331,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"1723752","pmcid":null,"openalex_id":"https://openalex.org/W2075548616","authors":[],"funders":[],"total_grants":0,"fwci":7.36,"citation_percentile":0.96707589,"influential_citations":0,"citation_trend":[{"year":2014,"count":2},{"year":2015,"count":3},{"year":2017,"count":3},{"year":2019,"count":2},{"year":2020,"count":1},{"year":2021,"count":2},{"year":2022,"count":1},{"year":2023,"count":2},{"year":2024,"count":1},{"year":2026,"count":1}],"oa_status":"closed","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpath.1711650406","host_type":"publisher"},{"url":"https://pathsocjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/path.1711650406","host_type":"publisher"},{"url":"https://doi.org/10.1002/path.1711650406","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/1723752","host_type":"repository"}],"fields_of_study":["Wound Healing and Treatments","Blood properties and coagulation","Angiogenesis and VEGF in Cancer","Medicine","Biology","Animals","Endopeptidases","Fibrin","Fibrin Fibrinogen Degradation Products","Fibrinolysis","Male","Mice","Mice, Inbred Strains","Neovascularization, Pathologic","Regional Blood Flow","Skin","Specimen Handling","Wound Healing"],"mesh_terms":["Animals","Fibrin","Fibrin Fibrinogen Degradation Products","Fibrinolysis","Male","Mice, Inbred Strains","Neovascularization, Pathologic","Endopeptidases","Regional Blood Flow","Skin","Specimen Handling","Wound Healing","Mice"],"keywords":["Fibrinolysis","Wound healing","Angiogenesis","Medicine","Intensive care medicine","Surgery","Internal medicine"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-11T00:02:37.411741Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}