{"doi":"10.1002/path.1416","title":"Integrins in regulation of tissue development and function","abstract":"<jats:title>Abstract</jats:title><jats:p>An erratum for this article has been published in <jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" ext-link-type=\"doi\" xlink:href=\"10.1002/path.1472\">Journal of Pathology; 201(4): 632–641.</jats:ext-link></jats:p><jats:p>Cell adhesion is indispensable for embryonic development and for proper tissue function. In metazoans, integrins are the major adhesion receptors that connect cells to components of the extracellular matrix. Integrins are implicated in assembly of extracellular matrices, cell adhesion and migration on extracellular matrices, and in vertebrates (in which the integrin family has expanded) they can also mediate cell–cell adhesion. Furthermore, integrin‐mediated adhesion can modulate many different signal transduction cascades and support cell survival, proliferation, and influence the expression of differentiation‐related genes. In this review we briefly explain how integrins can affect so many different aspects of cell behavior and discuss evidence for roles of integrins in tissue development, function, and disease. Copyright © 2003 John Wiley &amp; Sons, Ltd.</jats:p>","journal":"The Journal of Pathology","year":2003,"id":21662,"datarank":12.392037739308398,"base_score":5.765191102784844,"endowment":5.765191102784844,"self_citation_contribution":0.8647786654177267,"citation_network_contribution":11.52725907389067,"self_endowment_contribution":0.8647786654177267,"citer_contribution":11.52725907389067,"corpus_percentile":null,"corpus_rank":null,"citation_count":318,"citer_count":200,"citers_with_citation_signal":200,"citers_with_endowment":200,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":138679,"name":"Arnoud Sonnenberg","orcid":null,"position":1,"is_corresponding":false},{"id":138678,"name":"Erik HJ Danen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":5.765191102784844,"endowment":5.765191102784844,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"12845614","pmcid":null,"openalex_id":"https://openalex.org/W2027029136","authors":[],"funders":[{"funder_name":"Dutch Cancer Society","grant_id":"NKI 1999-2117","title":null},{"funder_name":"Dutch Cancer Society","grant_id":"NKI 2001-2488","title":null}],"total_grants":2,"fwci":9.9618,"citation_percentile":0.99153592,"influential_citations":11,"citation_trend":[{"year":2012,"count":16},{"year":2013,"count":12},{"year":2014,"count":12},{"year":2015,"count":7},{"year":2016,"count":7},{"year":2017,"count":10},{"year":2018,"count":7},{"year":2019,"count":8},{"year":2020,"count":10},{"year":2021,"count":6},{"year":2022,"count":7},{"year":2023,"count":7},{"year":2024,"count":6},{"year":2025,"count":5}],"oa_status":"bronze","license":"http://onlinelibrary.wiley.com/termsAndConditions#vor","oa_locations":[{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/path.1416","host_type":"journal"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/path.1416","host_type":"BRONZE"},{"url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1002/path.1416","host_type":"publisher"},{"url":"https://api.wiley.com/onlinelibrary/tdm/v1/articles/10.1002%2Fpath.1416","host_type":"publisher"},{"url":"https://pathsocjournals.onlinelibrary.wiley.com/doi/pdf/10.1002/path.1416","host_type":"publisher"},{"url":"https://doi.org/10.1002/path.1416","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/12845614","host_type":"repository"},{"url":"https://pubmed.ncbi.nlm.nih.gov/14648669","host_type":"repository"}],"fields_of_study":["Cell Adhesion Molecules Research","Cellular Mechanics and Interactions","Protease and Inhibitor Mechanisms","Biology","Medicine","Animals","Cell Adhesion","Cell Differentiation","Cell Division","Cell Physiological Phenomena","Embryonic Induction","Extracellular Matrix","Humans","Integrins","Mice","Signal Transduction"],"mesh_terms":["Animals","Cell Adhesion","Cell Differentiation","Cell Division","Cell Physiological Phenomena","Embryonic Induction","Extracellular Matrix","Humans","Signal Transduction","Integrins","Mice"],"keywords":["Integrin","Extracellular matrix","Cell biology","Cell adhesion","Cell adhesion molecule","Biology","Signal transduction","Adhesion","Extracellular","Function (biology)","Embryonic stem cell","Cell","Chemistry","Genetics","Gene"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-06T16:28:40.412486Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}