{"doi":"10.1002/osp4.660","title":"Offspring epigenetic markers at birth related to gestational BMI predict offspring BMI‐trajectories from infancy to 26 years","abstract":"Objective: To date, epigenetic studies identified differential DNA methylation (DNAm) related to gestational-body mass index (BMI) in offspring at birth. This study investigated whether the identified DNAm in offspring were also associated with BMI trajectories from infancy to age 26 years. Methods: Data of 794 participants from Isle of Wight birth cohort in UK were investigated to study association between BMI trajectories and DNAm related to gestational-BMI at birth. Multinominal logistic regression models were applied to test the association between 1090 DNAm sites reported in three prior epigenome-wide association studies and BMI trajectories. Results: ) were associated with early persistent obesity (EPO) and delayed overweight (DOW) trajectories respectively. A higher methylation of cg23089913 showed low odds of being in EPO trajectory (OR: 0.84; 95% CI: 0.76-0.93) while higher methylation of cg13217064 resulted in 1.4-times the odds of being in DOW trajectory when compared to the normal trajectory [Correction added on 22 February 2023, after first online publication: Range of the DNAm site cg23089913 has been changed from 'lower' to 'higher' in the preceding sentence.]. In a gender-stratified analysis, the odds of developing into DOW was 1.8 times in female participants for cg13217064 while not such association was observed in males. Conclusions: ) in newborns may change the risk of having excess body weight.","journal":"Obesity Science & Practice","year":2023,"id":384186,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7417,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":282191,"name":"Susan Ewart","orcid":"0000-0002-6462-7043","position":1,"is_corresponding":false},{"id":282199,"name":"Hongmei Zhang","orcid":"0000-0003-3557-0364","position":2,"is_corresponding":false},{"id":374447,"name":"Yu Jiang","orcid":"0000-0002-2437-9268","position":3,"is_corresponding":false},{"id":247757,"name":"Syed Hasan Arshad","orcid":"0000-0001-5988-235X","position":4,"is_corresponding":false},{"id":734695,"name":"Ali H. Ziyab","orcid":"0000-0003-3099-4424","position":5,"is_corresponding":false},{"id":282201,"name":"Wilfried Karmaus","orcid":"0000-0003-2684-1492","position":6,"is_corresponding":false},{"id":1151461,"name":"Vimala Devi Janjanam","orcid":"0000-0001-9279-0625","position":0,"is_corresponding":true}],"reference_count":31,"raw_metadata":null,"created_at":"2026-07-19T01:17:33.041385Z","pmid":"37546290","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}