{"doi":"10.1002/ohn.942","title":"Alzheimer's Disease‐Related Analytes Amyloid‐β and Tau in Perilymph: Correlation With Patient Age and Cognitive Score","abstract":"Abstract Objective To describe the collection methods for perilymph fluid biopsy during cochlear implantation, detect levels of amyloid β 42 and 40 (Aβ 42 and Aβ 40 ), and total tau (tTau) analytes with a high‐precision assay, to compare these levels with patient age and Montreal Cognitive Assessment (MoCA) scores, and explore potential mechanisms and relationships with otic pathology. Study Design Prospective study. Setting Tertiary referral center. Methods Perilymph was collected from 25 patients using polyimide tubing to avoid amyloid adherence to glass, and analyzed with a single‐molecule array advanced digital enzyme‐linked immunosorbent assay platform for Aβ 40 , Aβ 42 , and tTau. Cognition was assessed by MoCA. Results Perilymph volumes ranged from ∼1 to 13 µL, with analyte concentrations spanning 2.67 to 1088.26 pg/mL. All samples had detectable levels of tTau, Aβ 40 , and Aβ 42 , with a significant positive correlation between Aβ 42 and Aβ 40 levels. Levels of Aβ 42 , Aβ 40 , and tTau were positively correlated with age, while MoCA scores were inversely correlated with age. tTau and Aβ 42 /Aβ 40 ‐ratios were significantly correlated with MoCA scores. Conclusion Alzheimer's disease‐associated peptides Aβ 42 , Aβ 40 , and tau analytes are detectable in human perilymph at levels approximately 10‐fold lower than those found in cerebrospinal fluid (CSF). These species increase with age and correlate with cognitive impairment indicators, suggesting their potential utility as biomarkers for cognitive impairment in patients undergoing cochlear implantation. Future research should investigate the origin of these analytes in the perilymph and their potential links to inner ear pathologies and hearing loss, as well as their relationships to CSF and plasma levels in individuals.","journal":"Otolaryngology","year":2024,"id":471730,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9436,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":734726,"name":"Matthew Shew","orcid":"0000-0002-7971-377X","position":1,"is_corresponding":false},{"id":499014,"name":"Nedim Durakovic","orcid":"0000-0002-1391-2768","position":2,"is_corresponding":false},{"id":862276,"name":"Jacques A. Herzog","orcid":"0000-0003-2535-4086","position":3,"is_corresponding":false},{"id":317782,"name":"John R. Cirrito","orcid":"0000-0002-7196-8786","position":4,"is_corresponding":false},{"id":225564,"name":"Carla M. Yuede","orcid":"0000-0001-6362-4767","position":5,"is_corresponding":false},{"id":862275,"name":"Cameron C. Wick","orcid":"0000-0003-1779-2385","position":6,"is_corresponding":false},{"id":230678,"name":"Melissa Manis","orcid":"0000-0001-7912-2016","position":7,"is_corresponding":false},{"id":27592,"name":"David M. Holtzman","orcid":"0000-0002-3400-0856","position":8,"is_corresponding":false},{"id":361109,"name":"Craig A. Buchman","orcid":"0000-0002-9719-9727","position":9,"is_corresponding":false},{"id":371025,"name":"Mark A. Rutherford","orcid":"0000-0002-2627-6254","position":10,"is_corresponding":false},{"id":693472,"name":"Amit Walia","orcid":"0000-0002-1061-0561","position":0,"is_corresponding":true}],"reference_count":58,"raw_metadata":null,"created_at":"2026-07-19T02:05:48.788780Z","pmid":"39189154","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}