{"doi":"10.1002/oby.24366","title":"Association of Glucagon‐Like Peptide‐1 Receptor Agonists With Cancer Risk in Older Adults With Type 2 Diabetes","abstract":"OBJECTIVE: The real-world evidence on the association between glucagon-like peptide-1 receptor agonists (GLP-1RAs) and cancer risk remains limited and mixed. METHODS: In 2013-2020 national Medicare claims data, we included cancer-naïve patients with type 2 diabetes (T2D). We identified those who initiated GLP-1 RA, sodium-glucose cotransporter 2 inhibitor (SGLT2i), or dipeptidyl peptidase 4 inhibitor (DPP4i) and conducted 1:1 propensity score matching for confounding adjustment. Cox proportional hazards models were used to estimate hazard ratios (HR) of nine obesity-associated cancers (thyroid, pancreatic, bladder, colorectal, lung, kidney, breast, endometrial, and prostate cancer). RESULTS: In the matched GLP-1RA versus SGLT2i cohort (n = 21,362 pairs), GLP-1RA users had similar overall cancer risk with SGLT2i users (HR, 1.03 [95% CI, 0.95-1.12]), but GLP-1RAs were associated with an increased kidney cancer risk (HR, 1.43 [1.06-1.92]). In the matched GLP-1RA versus DPP4i cohort (n = 20,962 pairs), the GLP-1RA versus DPP4i comparison showed no significant difference in overall cancer risk (HR, 0.96 [0.89-1.04]) but revealed a significantly elevated endometrial cancer risk (HR, 1.55 [1.01-2.37]). CONCLUSION: GLP-1RAs might be associated with an increased risk of certain cancer types. Future studies are needed to validate the potential tumorigenic risk associated with GLP1-RAs.","journal":"Obesity","year":2025,"id":514463,"datarank":0.3830737439487449,"base_score":2.3978952727983707,"endowment":2.3978952727983707,"self_citation_contribution":0.3596842909197557,"citation_network_contribution":0.023389453028989184,"self_endowment_contribution":0.3596842909197557,"citer_contribution":0.023389453028989184,"corpus_percentile":null,"corpus_rank":null,"citation_count":10,"citer_count":9,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8493,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1372176,"name":"Hao Dai","orcid":"0000-0002-8418-0744","position":1,"is_corresponding":false},{"id":545934,"name":"Huilin Tang","orcid":"0000-0002-5814-6657","position":2,"is_corresponding":false},{"id":404842,"name":"William T. Donahoo","orcid":"0000-0002-2126-860X","position":3,"is_corresponding":false},{"id":263950,"name":"Thomas J. George","orcid":"0000-0002-6249-9180","position":4,"is_corresponding":false},{"id":278178,"name":"Ramon C. Sun","orcid":"0000-0002-3009-1850","position":5,"is_corresponding":false},{"id":55231,"name":"Sizun Jiang","orcid":"0000-0001-6149-3142","position":6,"is_corresponding":false},{"id":261753,"name":"Aik Choon Tan","orcid":"0000-0003-2955-8369","position":7,"is_corresponding":false},{"id":263949,"name":"Yi Guo","orcid":"0000-0003-0587-4105","position":8,"is_corresponding":false},{"id":237415,"name":"Jonathan D. Licht","orcid":"0000-0002-3942-1369","position":9,"is_corresponding":false},{"id":818071,"name":"John M. Allen","orcid":"0000-0002-0033-4508","position":10,"is_corresponding":false},{"id":351783,"name":"Kelvin P. Lee","orcid":"0000-0003-2587-0734","position":11,"is_corresponding":false},{"id":415391,"name":"Jingchuan Guo","orcid":"0000-0001-9799-2592","position":12,"is_corresponding":false},{"id":23318,"name":"Jiang Bian","orcid":"0000-0002-2238-5429","position":13,"is_corresponding":false},{"id":1377100,"name":"Ying Lu","orcid":"0009-0007-0674-3015","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:48:29.165853Z","pmid":"40841345","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}