{"doi":"10.1002/oby.24242","title":"Associations between decreases in adiposity and reductions in <scp>HbA1c</scp> and insulin use in the Look <scp>AHEAD</scp> cohort","abstract":"OBJECTIVE: The objective of this study was to elucidate associations between adiposity reduction and changes in HbA1c and insulin use among adults with type 2 diabetes and overweight or obesity. METHODS: Changes in BMI, waist circumference, and total percent fat mass were obtained over 8 years among 1316 individuals (aged 45-76 years) enrolled in the Look AHEAD (Action for Health in Diabetes) clinical trial of weight loss. Generalized linear models were used to assess relationships between 5% decreases in adiposity measures with glycated hemoglobin (HbA1c) and insulin use over time. RESULTS: A 5% reduction in total percent fat was associated with 0.15% (95% CI: 0.12%-0.18%) lower mean HbA1c. Similarly, 5% reductions in waist circumference and BMI were also associated with slightly lower mean HbA1c: 0.16% (95% CI: 0.13%-0.19%) and 0.13% (95% CI: 0.11%-0.16%), respectively. These reductions were associated with lower odds of insulin use over time, ranging from 21% lower odds for a 5% reduction in percent body fat to 32% lower odds for 5% reductions in waist circumference and BMI. Associations were evident across subgroups defined by sex, diabetes duration, obesity status, and intervention assignment. CONCLUSIONS: Reductions in adiposity are associated with stabilized and slightly lower HbA1c and a marked reduction in the need for insulin therapy. These benefits generalize across clinical subgroups.","journal":"Obesity","year":2025,"id":530348,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":5,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7158,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":251505,"name":"Rebecca H. Neiberg","orcid":"0000-0003-0719-6520","position":1,"is_corresponding":false},{"id":375885,"name":"Kristen M. Beavers","orcid":"0000-0002-7786-4195","position":2,"is_corresponding":false},{"id":249041,"name":"Steven E. Kahn","orcid":"0000-0001-7307-9002","position":3,"is_corresponding":false},{"id":307708,"name":"Denise K. Houston","orcid":"0000-0002-3355-4304","position":4,"is_corresponding":false},{"id":305437,"name":"Lynne E. Wagenknecht","orcid":"0000-0002-9980-0889","position":5,"is_corresponding":false},{"id":243121,"name":"Karen Johnson","orcid":"0000-0002-3493-4077","position":6,"is_corresponding":false},{"id":367542,"name":"Henry J. Pownall","orcid":"0000-0001-8412-506X","position":7,"is_corresponding":false},{"id":226606,"name":"Mark A. Espeland","orcid":"0000-0002-3711-1949","position":8,"is_corresponding":false},{"id":1410413,"name":"For the Action for Health in Diabetes (Look AHEAD) Aging Study Group","orcid":null,"position":9,"is_corresponding":false},{"id":1410064,"name":"Rebecca Palmer","orcid":"0009-0004-2030-7031","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":null,"created_at":"2026-07-19T02:51:05.836974Z","pmid":"39904719","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}