{"doi":"10.1002/oby.24156","title":"Combined diet and exercise training decreases serum lipids associated with insulin resistance","abstract":"OBJECTIVE: Circulating lipids are linked with insulin resistance and increased cardiovascular disease risk. We previously reported that dihydroceramides, a specific type of sphingolipid, are elevated in insulin-resistant individuals; however, little is known regarding whether insulin-sensitizing lifestyle interventions can improve profiles of sphingolipids and other lipid species. METHODS: A total of 21 individuals with obesity participated in a 3-month lifestyle intervention of combined weight loss and exercise training. Insulin sensitivity was assessed by hyperinsulinemic-euglycemic clamps, and serum lipidomics was conducted. RESULTS: peak and insulin sensitivity increased by 12% and 57%, respectively; and total serum triacylglycerol (TAG), diacylglycerol, dihydroceramides, sphingosine-1-phosphate, and sphinganine-1-phosphate were significantly reduced, as were specific species of dihydroceramides (C18:0 and C24:1). Individuals with higher preintervention TAG concentrations had significant decreases in serum lipids, which were not significantly changed in individuals with lower preintervention TAG. CONCLUSIONS: These data show that serum sphingolipid species previously linked to insulin resistance in humans can be reduced with insulin-sensitizing lifestyle interventions. Furthermore, individuals with elevated serum TAG may significantly benefit from lifestyle interventions that increase insulin sensitivity due to a greater decrease in serum lipids related to insulin resistance.","journal":"Obesity","year":2024,"id":443761,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8712,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":853126,"name":"Amanda Garfield","orcid":"0009-0006-1449-4939","position":1,"is_corresponding":false},{"id":495436,"name":"Simona Zarini","orcid":"0000-0002-7460-3299","position":2,"is_corresponding":false},{"id":299329,"name":"Joseph T. Brozinick","orcid":"0000-0002-7946-3432","position":3,"is_corresponding":false},{"id":269856,"name":"Leigh Perreault","orcid":"0000-0002-1481-7535","position":4,"is_corresponding":false},{"id":371803,"name":"Sean A. Newsom","orcid":"0000-0003-0585-3830","position":5,"is_corresponding":false},{"id":395392,"name":"Darcy Kahn","orcid":"0000-0002-3764-1202","position":6,"is_corresponding":false},{"id":496510,"name":"Anna A. Kerege","orcid":null,"position":7,"is_corresponding":false},{"id":853940,"name":"Karin Zemski Berry","orcid":null,"position":8,"is_corresponding":false},{"id":530943,"name":"Hai H. Bui","orcid":null,"position":9,"is_corresponding":false},{"id":235337,"name":"Bryan C. Bergman","orcid":"0000-0002-9561-1052","position":10,"is_corresponding":false},{"id":408600,"name":"Josiane L. Broussard","orcid":"0000-0002-6824-8294","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T02:01:29.001453Z","pmid":"39587896","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}