{"doi":"10.1002/oby.24046","title":"Low‐calorie diet‐induced weight loss is associated with altered brain connectivity and food desire in obesity","abstract":"OBJECTIVE: The main objective of this study is to better understand the effects of diet-induced weight loss on brain connectivity in response to changes in glucose levels in individuals with obesity. METHODS: A total of 25 individuals with obesity, among whom 9 had a diagnosis of type 2 diabetes, underwent functional magnetic resonance imaging (fMRI) scans before and after an 8-week low-calorie diet. We used a two-step hypereuglycemia clamp approach to mimic the changes in glucose levels observed in the postprandial period in combination with task-mediated fMRI intrinsic connectivity distribution (ICD) analysis. RESULTS: After the diet, participants lost an average of 3.3% body weight. Diet-induced weight loss led to a decrease in leptin levels, an increase in hunger and food intake, and greater brain connectivity in the parahippocampus, right hippocampus, and temporal cortex (limbic-temporal network). Group differences (with vs. without type 2 diabetes) were noted in several brain networks. Connectivity in the limbic-temporal and frontal-parietal brain clusters inversely correlated with hunger. CONCLUSIONS: A short-term low-calorie diet led to a multifaceted body response in patients with obesity, with an increase in connectivity in the limbic-temporal network (emotion and memory) and hormone and eating behavior changes that may be important for recovering the weight lost.","journal":"Obesity","year":2024,"id":475813,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.954,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":514565,"name":"Cheryl Lacadie","orcid":"0009-0006-3130-4156","position":1,"is_corresponding":false},{"id":301735,"name":"Janice J. Hwang","orcid":"0000-0002-8395-5659","position":2,"is_corresponding":false},{"id":1313130,"name":"Katherine Lam","orcid":null,"position":3,"is_corresponding":false},{"id":1312752,"name":"Ahmed Elshafie","orcid":"0000-0002-1000-5345","position":4,"is_corresponding":false},{"id":1312753,"name":"Samuel B. Rosenberg","orcid":"0000-0003-0537-9729","position":5,"is_corresponding":false},{"id":303294,"name":"Charles Watt","orcid":null,"position":6,"is_corresponding":false},{"id":235364,"name":"Rajita Sinha","orcid":"0000-0003-3012-4349","position":7,"is_corresponding":false},{"id":282066,"name":"R. Todd Constable","orcid":"0000-0001-5661-9521","position":8,"is_corresponding":false},{"id":524896,"name":"Mary Savoye","orcid":null,"position":9,"is_corresponding":false},{"id":284851,"name":"Dongju Seo","orcid":"0009-0009-6641-0495","position":10,"is_corresponding":false},{"id":1312754,"name":"Renata Belfort‐DeAguiar","orcid":"0000-0002-4357-0447","position":11,"is_corresponding":false},{"id":1312751,"name":"H.G. Hoang","orcid":"0000-0002-0842-7848","position":0,"is_corresponding":true}],"reference_count":44,"raw_metadata":null,"created_at":"2026-07-19T02:06:21.071690Z","pmid":"38831482","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}