{"doi":"10.1002/oby.23808","title":"Reducing BMI below the obesity threshold in adolescents treated with once‐weekly subcutaneous semaglutide 2.4 mg","abstract":"OBJECTIVE: The aim of this study was to examine how improvement in BMI with the glucagon-like peptide-1 receptor agonist semaglutide translated to changes in BMI category in a post hoc analysis of the double-blind, phase 3a randomized controlled Semaglutide Treatment Effect in People with obesity (STEP) TEENS trial. METHODS: Adolescents with obesity received once-weekly subcutaneous semaglutide 2.4 mg or placebo plus lifestyle intervention, which comprised counseling in healthy nutrition and a goal of 60 minutes of moderate- to high-intensity physical activity per day. Achievement of an improvement in BMI category and attainment of normal-weight or overweight BMI by week 68 were analyzed using logistic regression models. RESULTS: In the overall population, 44.9% of participants receiving semaglutide achieved weight reduction resulting in reclassification to a normal-weight or overweight BMI category versus 12.1% receiving placebo at week 68 (odds ratio: 22.7; 95% CI: 7.6-67.9). The proportion of semaglutide-treated participants in obesity class III decreased from 37.3% to 13.6% but increased with placebo. The odds ratio for achieving an improvement of at least one BMI category was significantly greater with semaglutide versus placebo (23.5; 95% CI: 9.9-55.5); an improvement of at least one BMI category was seen in 73.7% of participants receiving semaglutide compared with 19.0% of participants receiving placebo. CONCLUSIONS: Semaglutide was highly effective in reducing BMI category. While on treatment, most trial participants' BMI improved by at least one category, and >40% reached a category below the obesity threshold.","journal":"Obesity","year":2023,"id":320239,"datarank":1.5662595739861052,"base_score":3.9318256327243257,"endowment":3.9318256327243257,"self_citation_contribution":0.5897738449086489,"citation_network_contribution":0.9764857290774562,"self_endowment_contribution":0.5897738449086489,"citer_contribution":0.9764857290774562,"corpus_percentile":null,"corpus_rank":null,"citation_count":50,"citer_count":42,"citers_with_citation_signal":27,"citers_with_endowment":27,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9611,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT04102189"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":448934,"name":"Silva Arslanian","orcid":"0000-0002-1528-9324","position":1,"is_corresponding":false},{"id":1030774,"name":"Dan Hesse","orcid":"0000-0002-9670-6037","position":2,"is_corresponding":false},{"id":867339,"name":"Aske Thorn Iversen","orcid":"0000-0002-7096-1144","position":3,"is_corresponding":false},{"id":271409,"name":"Antje Körner","orcid":"0000-0001-6001-0356","position":4,"is_corresponding":false},{"id":1030775,"name":"Signe Schmidt","orcid":"0000-0002-6968-6675","position":5,"is_corresponding":false},{"id":1030776,"name":"Rasmus Sørrig","orcid":"0000-0002-0059-1555","position":6,"is_corresponding":false},{"id":911370,"name":"Daniel Weghuber","orcid":"0000-0002-4389-0379","position":7,"is_corresponding":false},{"id":648510,"name":"Ania M. Jastreboff","orcid":"0000-0003-1446-0991","position":8,"is_corresponding":false},{"id":245454,"name":"Aaron S. Kelly","orcid":"0000-0001-8530-107X","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T01:07:22.377587Z","pmid":"37196421","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}