{"doi":"10.1002/oby.23618","title":"Effect of behavioral weight‐loss program on biomarkers of cardiometabolic disease risk: Heart Health Study randomized trial","abstract":"OBJECTIVE: This study aimed to determine whether novel biomarkers of cardiometabolic health improve in response to a 12-month behavioral weight-loss intervention and to compare benefits of diet alone with diet plus physical activity for these biomarkers. METHODS: Participants (N = 374) were randomized to either diet alone (DIET), diet plus 150 min/wk of prescribed moderate-intensity physical activity (DIET + PA150), or diet plus 250 min/wk of prescribed moderate-intensity physical activity (DIET + PA250). Biomarker concentrations were determined using nuclear magnetic resonance spectroscopy. Mixed models assessed for a time effect, group effect, or group by time interaction. RESULTS: All groups significantly improved body weight (time: p < 0.0001), Lipoprotein Insulin Resistance Index score (time: p < 0.0001), Diabetes Risk Index score (time: p < 0.0001), branched-chain amino acid concentration (time: p < 0.0001), and GlycA concentration (time: p < 0.0001), with no group effect or group by time interactions. CONCLUSIONS: All intervention groups prompted a notable beneficial change among biomarkers of insulin resistance and cardiometabolic health. However, the addition of at least moderate-intensity physical activity to a diet-only intervention did not provide any additional benefit. These findings highlight that an average weight loss of approximately 10% profoundly impacts biomarkers of insulin resistance and cardiometabolic disease in adults with overweight or obesity.","journal":"Obesity","year":2023,"id":370542,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9342,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":231464,"name":"William E. Kraus","orcid":"0000-0003-1930-9684","position":1,"is_corresponding":false},{"id":235353,"name":"Renee J. Rogers","orcid":"0000-0001-7635-4751","position":2,"is_corresponding":false},{"id":11396,"name":"Elizabeth R. Hauser","orcid":"0000-0003-0367-9189","position":3,"is_corresponding":false},{"id":251507,"name":"Wei Lang","orcid":"0000-0002-8853-4458","position":4,"is_corresponding":false},{"id":236704,"name":"Rong Jiang","orcid":"0000-0003-0757-9310","position":5,"is_corresponding":false},{"id":450760,"name":"Erik B. Schelbert","orcid":"0000-0003-0356-4437","position":6,"is_corresponding":false},{"id":235342,"name":"Kim M. Huffman","orcid":"0000-0003-4708-4734","position":7,"is_corresponding":false},{"id":235351,"name":"John M. Jakicic","orcid":"0000-0001-6800-9368","position":8,"is_corresponding":false},{"id":725975,"name":"Katherine A. Collins","orcid":"0000-0001-9712-8980","position":0,"is_corresponding":true}],"reference_count":45,"raw_metadata":null,"created_at":"2026-07-19T01:15:41.237096Z","pmid":"36621902","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}