{"doi":"10.1002/oby.23579","title":"The basis and design for time‐restricted eating compared with daily calorie restriction for weight loss and colorectal cancer risk reduction trial (<scp>TRE‐CRC</scp> trial)","abstract":"OBJECTIVE: Approximately 42% of American adults are living with obesity, increasing their risk of colorectal cancer (CRC). Efficacious approaches to prevent and treat obesity may reduce CRC incidence. Daily calorie restriction (Cal-R) is the most common approach to treating obesity, yet clinically meaningful weight loss is elusive owing to waning adherence. Time-restricted eating (TRE) consists of consuming foods within a specified time frame, creating a natural calorie deficit. TRE in animals shows cancer protective effects. In humans, TRE is safe and acceptable among adults with obesity, producing ~3% to 5% weight loss and reductions in oxidative stress and insulin resistance. However, TRE has not been tested rigorously for CRC preventive effects. METHODS: The authors describe a 12-month randomized controlled trial of 8-hour TRE (ad libitum 12 PM-8 PM), Cal-R (25% restriction daily), or Control among 255 adults at increased risk for CRC and with obesity. RESULTS: Effects on the following will be examined: 1) body weight, body composition, and adherence; 2) circulating metabolic, inflammation, and oxidative stress biomarkers; 3) colonic mucosal gene expression profiles and tissue microenvironment; and 4) maintenance of benefits on body weight/composition and CRC risk markers. CONCLUSIONS: This study will examine efficacious lifestyle strategies to treat obesity and reduce CRC risk among individuals with obesity.","journal":"Obesity","year":2022,"id":280953,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9549,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":373541,"name":"Marian Fitzgibbon","orcid":"0000-0002-7735-2165","position":1,"is_corresponding":false},{"id":362376,"name":"Cemal Yazıcı","orcid":"0000-0003-4839-0354","position":2,"is_corresponding":false},{"id":783681,"name":"Peter H. Gann","orcid":"0000-0002-9439-2900","position":3,"is_corresponding":false},{"id":333917,"name":"Maria Sverdlov","orcid":"0000-0002-1893-865X","position":4,"is_corresponding":false},{"id":320642,"name":"Grace Guzman","orcid":"0000-0001-7256-7223","position":5,"is_corresponding":false},{"id":254870,"name":"Zhengjia Chen","orcid":"0000-0002-6301-4931","position":6,"is_corresponding":false},{"id":366025,"name":"Andrew McLeod","orcid":"0000-0002-7067-3441","position":7,"is_corresponding":false},{"id":363176,"name":"Alyshia Hamm","orcid":null,"position":8,"is_corresponding":false},{"id":225438,"name":"Krista A Varady","orcid":"0000-0002-9279-9934","position":9,"is_corresponding":false},{"id":333874,"name":"Lisa Tussing‐Humphreys","orcid":"0000-0002-7015-2961","position":10,"is_corresponding":false},{"id":225431,"name":"Kelsey Gabel","orcid":"0000-0003-4613-8892","position":0,"is_corresponding":true}],"reference_count":46,"raw_metadata":null,"created_at":"2026-07-19T00:29:07.472902Z","pmid":"36319597","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}